http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (x, 441 pages) : illustrations
The subject of aluminium and Alzheimer's disease has been plagued with controversy. This controversy has served to obscure much of the scientific research in this field, and subsequently has obscured the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease. This book brings together many of the world's leading scientists researching aluminium and life and contains their critical summaries on the known facts about aluminium toxicity in man and to offer an opinion on the implications of this knowledge on a link between aluminium and Alzheimer's disease. The subject areas of the chapters were chosen to reflect the myriad of ways that aluminium is known to impact upon mammalian physiology and function and range from clinical studies, through animal models of disease to the detailed biochemistry of aluminium toxicity. Chapters are also included on epidemiology and other factors involved in the aetiology of Alzheimer's. This is the first time that this subject has been treated in such a comprehensive manner. The research detailed in each chapter, includes the latest research in the field, it has been critically appraised and this appraisal has been used by each author to present an informed opinion of its relevance to aluminium and Alzheimer's disease. The chapters are much more than reviews; they are a statement of the state of the art and of what the future may hold for research in this field. As a whole they show the high quality of research that has been carried out in our efforts to understand the toxicity of aluminium in man and that we are far away from discounting the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease.
Why is research into aluminium and life important? / Paul Altmann -- aluminum-induced bone disease : implications for Alzheimer's disease / Kenneth Abreo -- The epidemiology of aluminium and Alzheimer's disease / Virginie Rondeau and Daniel Commenges -- Absorption of aluminum from antiperspirants and vaccine adjuvants / Richard Flarend -- The aetiology of Alzheimer's disease : diverse routes into a common tau pathway / Charles R. Jarrington -- The association of aluminum and neurofibrillary degeneration in Alzheimer's disease, a personal perspective / Daniel P. Perl -- Aluminum and gene transcription in the mammalian central nervous system : implications for Alzheimer's disease / Walter J. Lukiw -- Behavioral studies in animals : past and potential contribution to the understanding of the relationship between aluminum and Alzheimer's disease / Mari S. Golub -- Aluminum as an experimental neurotoxicant : the neuropathology and neurochemistry / Michael J. Strong -- The rabbit model system for studies of aluminum-induced neurofibrillary degeneration : relevance to human neurodegenerative disorders / John Savory, Othman Ghribi, Michael S. Forbes and Mary M. Herman -- Aluminium and iron : implications for Alzheimer's disease / Patrick C. D'haese and Marc E. De Broe -- Aluminum and the blood-brain barrier / Robert A. Yokel -- Aluminium toxicity in erythropoiesis : mechanisms related to cellular dysfunction in Alzheimer's disease / Alcira Nesse and Graciela Garbossa -- Aluminum, membranes and Alzheimer's disease / Paolo Zatta and Mario Suwalsky -- Iron homeostasis and aluminium toxicity / Roberta J. Ward and Robert R. Crichton -- Oxidative and inflammatory properties of aluminum : possible relevance in Alzheimer's disease / Stephen C. Bondy and Arezoo Campbell -- Glutamatergic neurotransmission, aluminium and Alzheimer's disease / Vicente Felipo -- Aluminum-induced alteration of phosphoinositide and calcium signaling / William R. Mundy and Timothy J. Shafer -- The interaction of aluminium with peptides and proteins / Tamás Kiss and Miklós Hollósi -- Calmodulin, aluminium and Alzheimer's disease / Beka Solomon -- Aluminum, tau and neurofibrillary degeneration / Ryong-Woon Shin -- The association of aluminium and [beta] amyloid in Alzheimer's disease / Christopher Exley and Olga Korchazhkina.
Includes bibliographical references and index.
123012:128444 Elsevier Science & Technology