rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: HPLC Method Development for Pharmaceuticals
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: xx
    publisher: Academic Pr
    date issued: 2007
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  abstract: High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective. HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge. * Covers the requirements for HPLC in a pharmaceutical setting including strategies for software and hardware validation to allow for use in a regulated laboratory * Provides an overview of the pharmaceutical development process (clinical phases, chemical and pharmaceutical development activities) * Discusses how HPLC is used in each phase of pharmaceutical development and how methods are developed to support activities in each phase.
  table of contents: 1. Overview (Satinder Ahuja). -- 2. HPLC Theory (Y.V. Kazakevich). -- 3. HPLC Columns and Packings (U.D. Neue et al.). -- 4. Column Characterization and Selection (D. Visky). -- 5. Chiral Separations (Xiande Wang et al.). -- 6. Contemporary Liquid Chromatographic Systems for Method Development (M. Swartz). -- 7. Hyphenated Techniques (D.L. Norwood et al.). -- 8. HPLC Sample Preparation (G. Slack, N.H. Snow). -- 9. Instrument and Software Qualification and Validation (D. Van Geel). -- 10. Pharmaceutical Development: From Pre-clinical to Post Approval (K. Bynum). -- 11. HPLC Method Development for Drug Discovery LC-MS Assays in Rapid PK Applications (Xiaoying Xu, W. Korfmacher). -- 12. HPLC Method Development in Early Phase Pharmaceutical Development (H.T. Rasmussen et al.). -- 13. HPLC Method Development in Late Phase Pharmaceutical Development (M. Ilias Jimidar). -- 14. Use of HPLC for In-process Testing (C. Richardson). -- 15. Method Development for Biomolecules (D.E. Raynie, J.L. Driver). -- 16. Method Validation (M. Ilias Jimidar et al.). -- 17. Troubleshooting HPLC Methods (H. McNair). -- 18. Molecularly Imprinted Polymers as Sorbents for Separations and Extractions (M.T. Koesdjojo et al.).
  subject:
    topic: High performance liquid chromatography
    topic: Methodology
  subject:
    topic: Drugs
    topic: Analysis
  subject:
    topic: Drug development
  subject:
    topic: Pharmaceutical Preparations
    topic: analysis
  subject:
    topic: Chemistry, Pharmaceutical
    topic: methods
  subject:
    topic: Chromatography, High Pressure Liquid
    topic: methods
  subject:
    topic: Chromatographie en phase liquide à hautes performances
    topic: Méthodologie
  subject:
    topic: Médicaments
    topic: Analyse
  subject:
    topic: Médicaments
    topic: Développement
  subject:
    topic: Drug development
  subject:
    topic: Drugs
    topic: Analysis
  subject:
    topic: High performance liquid chromatography
    topic: Methodology
  classification: RS189.5.H54 H65 2007
  classification: 615/.1901
  related item:
    title info:
      title: HPLC Method Development for Pharmaceuticals
    origin info:
      publisher: Academic Pr, 2007
    identifier: (OCoLC)144220768
  identifier: 9780123705402
  identifier: 0123705401
  identifier: 116045:116143 Elsevier Science & Technology
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: OPELS
    record creation date: 070802
    record change date: 20260326150221.9
    record identifier: in00005731426
    language of cataloging:
      language term: eng