In vitro methods in pharmaceutical research /

In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Castell, José V., Gómez-Lechón, María José
Format: eBook
Language:English
Published: San Diego : Academic Press, ©1997.
Subjects:
Online Access:Connect to the full text of this electronic book

MARC

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260 |a San Diego :  |b Academic Press,  |c ©1997. 
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520 |a In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular in vitro models for toxicology and pharmacology studies. Key Features * Meets the continuing demand for information in this field * Compares In Vitro techniques with other methods * Describes cell-culture methods used to investigate toxicity in cells derived from different organs * Includes contributions by leading experts in the field. 
505 0 |a D.W. Straughan, J.H. Fentem, and M. Balls, Replacement Alternative and Complementary In Vitro Methods in Pharamaceutical Research. -- M.D. Barratt and M. Chamberlain, Integration of QSAR and In Vitro Toxicology. -- F.A. Barile, Continuous Cell Lines as a Model for Drug Toxicity Assessment. -- P. Bach, In Vitro Models for Nephrotoxicity Studies. -- A.E.M. Vickers, Experimental In Vitro Models to Evaluate Hepatotoxicity. -- M.J. Gomez-Lechon, T. Donato, X. Ponsoda, R. Fabra, R. Trullenque, and J.V. Castell, Isolation, Culture and Use of Human Hepatocytes in Drug Research. -- E. McFarlane-Abdulla, and I.C. Campbell, Studies of Nephrotoxicity in Cellular Studies. -- M. Adolphe, S. Thenet-Gauci, and S. Demignot, Chondrocyte Culture: A Target System to Evaluate Pharmaco-Toxicological Effects of Drugs. -- E. Chacon, D. Acosta, and J.J. Lemasters, Primary Cultures of Cardiac Myocytes as In Vitro Models for Pharmacological and Toxicological Assessments. -- R. Roguet, Cutaneous Pharmacotoxicology In Vitro. -- H. Spielmann, Ocular Irritation. -- M.A. Miranda, Phototoxicity of Drugs. -- I. de G. Mitchell and R.D. Combes, In Vitro Genotoxicity and Cell Transformation Assessment. -- B. Schmid, R. Bechter, and P. Kucera, The Use of Whole Embryo Cultures in In Vitro Teratogenicity Testing. -- J.V. Castell, M.J. Gomez-Lechon, X. Ponsoda, and R. Bort, In Vitro Investigation of the Molecular Mechanisms of Hepatotoxicity. -- A. Guillouzo, Biotransformation of Drugs by Hepatocytes. -- K. Mace, E.A. Offord, and A.M.A. Pfeifer, Drug Metabolism and Carcinogen Activation Studies with Human Genetically Engineered Cells. 
504 |a Includes bibliographical references and index. 
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