Excitatory amino acids : clinical results with antagonists /
Glutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chron...
| Corporate Author: | |
|---|---|
| Other Authors: | |
| Format: | eBook |
| Language: | English |
| Published: |
San Diego :
Academic Press,
©1997.
|
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
| Summary: | Glutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chronic pain, and schizophrenia. Excitatory amino acid receptor agonists and antagonists are therefore of major interest as potential drugs for central nervous system disorders. Excitatory Amino Acids is the first book entirely dedicated to the results of human testing of modulators of excitatory amino acid neurotransmitters. Features include: * Coverage of the field of excitatory amino acids from synaptic function to preclinical and clinical pharmacology * Description of the development of NMDA (Nmethyl-d-aspartate) and non-NMDA antagonists * Reports of potential drugs in early and late clinical stages of development. |
|---|---|
| Physical Description: | 1 online resource (xii, 156 pages) : illustrations |
| Format: | Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. |
| Bibliography: | Includes bibliographical references (pages 129-152) and index. |
| ISBN: | 9780125468206 0125468202 9780080531342 0080531342 |