http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (vii, 340 pages) : illustrations (some color).
Respiratory syncytial virus (RSV) was first identified half a century ago in 1956. Following its discovery, the virus soon became recognised as a major viral pathogen causing extensive outbreaks of respiratory tract infections in both the very young and in vulnerable adults. It is an unusual virus in that it can cause repeated reinfections throughout life. The topics covered within this volume are wide ranging in scope from the most basic molecular biology of the virus to the clinical picture of RSV in the developing world. The internationally recognised experts were invited not only to review the present state of knowledge but also to give their perspective on the current situation and to identify the gaps and future requirements for research in an effort to stimulate new cross-cutting approaches to tackle this major viral pathogen.
Cover -- Respiratory Syncytial Virus -- Copyright Page -- Contents -- Preface -- Molecular Biology of Human Respiratory Syncytial Virus -- Introduction -- The virion -- The infectious cycle -- Experimental systems to study the replicative cycle of HRSV -- Virus entry -- Transcription and replication of the viral genome -- Virus assembly -- Virus-host cell interactions -- Acknowledgements -- References -- Immunology of RSV -- The innate immune response -- The adaptive immune response -- Conclusions -- References -- Molecular Epidemiology and Evolution of RSV -- Introduction -- RSV groups and genotypes -- Structure of epidemics -- Geographic distribution of RSV strains -- The G protein -- Evolution of RSV -- Emergence of new lineages -- Disappearance of lineages -- Mechanism of selection of new strains -- Paradox -- Reinfection with RSV -- Conclusions -- References -- Genetic Susceptibility to RSV Disease -- Epidemiological evidence of genetic susceptibility to RSV infection in infancy -- Evidence that the host response rather than the virus is responsible for disease -- Requirements for effective genetic association studies -- Genetic association studies of RSV bronchiolitis -- Other studies -- General comments -- The future -- References -- Pathogenesis of RSV in Children -- Introduction -- Viral infection and cytotoxicity -- The immune response to infection -- Conclusion -- References -- RSV Infection in Elderly Adults -- Introduction -- Epidemiology -- Clinical manifestations and complications of RSV infection in elderly adults -- Diagnosis of RSV infection -- Treatment of RSV infection -- Prevention of RSV infection -- Conclusions -- References -- Respiratory Syncytial Virus Disease Burden in the Developing World -- Introduction -- Methods, definitions, limitations -- Denominator-based data on incidence -- Associated mortality -- Disease-causing agent or benign co-infection -- Risk factors for RSV infection -- Additional burdens of disease -- Temporal dynamics of RSV: Where and how does it persist -- Conclusions and future research needs -- Abbreviations -- References -- Vaccines against Human Respiratory Syncytial Virus -- Introduction: the burden of disease and the need for a vaccine -- Considerations in developing an RSV vaccine -- Formalin-inactivated RSV (FI-RSV) -- Subunit vaccines -- Live-attenuated RSV strains -- Live-vectored RSV vaccines -- DNA vaccines -- Perspective -- Acknowledgment -- References -- Development of Antivirals against Respiratory Syncytial Virus -- Introduction -- Slow progress -- Vaccines versus antivirals -- Brief history of RSV antiviral development -- Modern approaches to antiviral discovery -- Models of RSV disease -- Alternative model of human RSV in tissue culture -- Clinical trials of RSV agents -- Drugs in development -- Miscellaneous (unknown) mechanisms -- Inhibiting host cell functions -- Antisense compounds and siRNA -- Future prospects -- Acknowledgements -- References -- Pneumonia Virus of Mice -- The natural history of PVM -- Characteristics of the PVM virion -- The molecular biology of PVM -- PVM proteins -- Pathogenesis of PVM infection in inbred strains of mice: basic biology -- Explorations with the PVM infection model: therapeutic directions -- References.
Title from title screen (viewed Apr 29, 2007).
Includes bibliographical references and indexes.
Perspectives in medical virology ; v. 14