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Macromolecular crystallography : conventional and high-throughput methods /

This volume deals with high-throughput methods from cloning and crystallisation to refinement and modelling. It includes contributions from internationally recognized leaders offering chapters on conventional and high-throughput methods.

Bibliographic Details
Other Authors: Sanderson, Mark R., Skelly, Jane
Format: eBook
Language:English
Language Notes:English.
Published: Oxford, UK ; New York : Oxford University Press, 2007.
Series:Oxford biosciences
Subjects:
X-ray crystallography > Technique.
Macromolecules > Structure.
Macromolecular Substances > chemistry
Crystallography, X-Ray > methods
Radiocristallographie > Technique.
SCIENCE > Life Sciences > Biochemistry.
Macromolecules > Structure
X-ray crystallography > Technique
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Classical cloning, expression, and purification / Jane Skelly, Maninder K. Sohi, and Thil Batuwangala
  • High-throughput cloning, expression, and purification / Raymond J. Owens [and others]
  • Automation of non-conventional crystallization techniques for screening and optimization / Naomi E. Chayen
  • First analysis of macromolecular crystals / Sherin S. Abdel-Meguid, David Jeruzalmi and Mark R. Sanderson
  • In-house macromolecular data collection / Mark R. Sanderson
  • Solving the phase problem using isomorphous replacement / Sherin S. Abdel-Meguid
  • Molecular replacement techniques for high-throughput structure determination / Marc Delarue
  • MAD phasing / H.M. Krishna Murthy
  • Application of direct methods to macromolecular structure solution / Charles M. Weeks and William Furey
  • Phase refinement through density modification / Jan Pieter Abrahams [and others]
  • Getting a macromolecular model: model building, refinement, and validation / R.J. Morris, A. Perrakis and V.S. Lamzin
  • High-throughput crystallographic data collection at synchrotrons / Stephen R. Wasserman [and others]
  • Electron density fitting and structure validation / Mike Carson
  • RNA crystallogenesis / Benoît Masquida [and others]
  • Crystallography in the study of protein-DNA interaction / Maninder K. Sohi and Ivan Laponogov
  • Virus crystallography / Elizabeth E. Fry, Nicola G.A. Abrescia and David I. Stuart
  • Macromolecular crystallography in drug design / Sherin S. Abdel-Meguid.