Practical instrumental analysis : methods, quality assurance and laboratory management /

The essential practical guide for analytical chemists working in industry, covering all the common methods used in industrial analytical labs. The author has a background in industry as well as extensive experience in teaching this topic, so he knows the field from the inside and can explain the con...

Full description

Bibliographic Details
Main Author:	Petrozzi, Sergio (Author)
Format:	eBook
Language:	English
Language Notes:	Text in English.
Published:	Weinheim, Germany : Wiley-VCH, [2013]
Subjects:	Instrumental analysis. Analytical chemistry > Instruments.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Department of Commerce (NIST)
3.3.8. Significant Figures-Box-and-Dot Method
3.3.9. Outlier Tests
3.3.9.1. 2.5 S Barrier
3.3.9.2. Test according to Grubbs
3.4. Regression
3.4.1. Regression Analysis
3.4.2. Calibration Function
3.4.3. Optimal Trend Line
3.4.4. Linear Regression
3.4.4.1. Linearity
3.4.4.2. Statistical Information from Linear Regression
3.4.4.3. Analytical Sensitivity
3.4.4.4. Correlation Coefficient (R)
3.4.4.5. Coefficient of Determination (R2)
3.4.4.6. Regression Equation
4. Analytical Process
4.1. Analytical Process in the Overall Context
4.2. Planning Phase
4.2.1. Analytical Problem
4.2.2. Object of Investigation
4.2.3. Sample
4.2.4. Sampling
4.2.4.1. Types of Sampling
4.2.4.2. Sampling Errors
4.2.4.3. Sample Handling
4.2.4.4. Difficulties of Sample Processing
4.2.5. Examination Procedures
4.2.6. Analyte
4.2.7. Literature and Database Research
4.2.7.1. Types of Chemical Literature
4.2.7.2. From the Question to the Document
4.2.7.3. From the Quotation to the Document
4.2.7.4. Question of Topic
4.2.7.5. Science Citation Index Expanded
4.2.7.6. Scopus
4.2.7.7. Medline
4.2.7.8. Current Information
4.2.7.9. Specific Types of Documents Such As Norms and Patents
4.3. Analysis
4.3.1. Measurement
4.3.2. Method Optimization
4.3.3. Calibration
4.3.3.1. External Calibration
4.3.3.2. Internal Standard (IStd)
4.3.3.3. Standard Addition Method (Spiking Method)
4.3.3.4. One-Time Addition
4.3.3.5. Multiple Additions
4.3.3.6. Recovery Standard (RStd)
4.4. Assessment
4.4.1. Quantification
4.4.1.1. Traceability
4.4.2. (True) Content
4.4.2.1. Terminology
4.5. Validation
4.5.1. Validation Elements
4.5.1.1. Selectivity/Specificity
4.5.1.2. Working Range
4.5.1.3. Detection, Determination and Quantitation Limit
4.5.1.4. German Standard DIN 32645
4.5.1.5. Calculations
4.5.1.6. Limit of Detection according to Kaiser
4.5.1.7. Robustness
4.5.2. Using the Computer
4.6. Final Documentation
4.6.1. Review
5. Example of a Validation Strategy
5.1. Determination of Phenol in Industrial Waste Water
5.1.1. Confirmation of Identity
5.1.1.1. Selectivity
5.1.1.2. Precision
5.1.2. Sample Content Determination
5.1.2.1. Accuracy
5.1.2.2. Calibration Function-Calibration, Linearity, Working Range
5.1.2.3. Determination of the Detection, Determination and Quantitation Limits according to DIN 32645-Direct and Indirect Method
5.1.2.4. Measurement Uncertainty
5.1.2.5. Robustness
5.1.3. Selection
5.1.3.1. Final Documentation
6. Organizational and Practical Procedures in the Teaching Laboratory Program
6.1. Goals
6.2. Safety in the Laboratory Class
6.3. Experimental Project Workflow
6.3.1. Preparation
6.3.2. Laboratory Notebook
6.4. Reports
References
7. Literature
7.1. Cited Literature
7.2. Recommended Norms (Selection)
7.2.1. Calibration
7.2.2. Inter-laboratory Tests
7.2.3. Quality Management
7.3. Suggested Books (Selection)
8. Projects
8.1. Chromatography
8.1.1. Gas Chromatography-GC, Project: Tanker Accident
8.1.1.1. Analytical Problem
8.1.1.2. Introduction
8.1.1.3. Material and Methods
8.1.1.4. Questions
References
8.1.2. Gas Chromatography Coupled with Mass Selective Detection-GC/MS, Project: Circumvention of the Formerly Mandatory Declaration of Fragrances in Perfumes?
8.1.2.1. Analytical Problem
8.1.2.2. Introduction
8.1.2.3. Material and Methods
8.1.2.4. Questions
References
8.1.3. High-Performance Liquid Chromatography-HPLC, Project: Stricter Control of Drugs
8.1.3.1. Analytical Problem
8.1.3.2. Introduction
8.1.3.3. Material and Methods
8.1.3.4. Questions
References
8.1.4. High-Performance Liquid Chromatography Coupled with Mass-Selective Detection-LC/MS, Project Cocaine Scandal: Hair Sample with Consequences
8.1.4.1. Analytical Problem
8.1.4.2. Introduction
8.1.4.3. Material and Methods
8.1.4.4. Questions
References
8.1.5. Ion Chromatography (IC), Project: Water Is Life
8.1.5.1. Analytical Problem
8.1.5.2. Introduction
8.1.5.3. Material and Methods
8.1.5.4. Questions
References
8.1.6. High-Performance Thin-Layer Chromatography (HPTLC), Project: Ensuring Regulatory Compliance by Quantification of Lead Compounds (Markers) in Herbal Combination Products
8.1.6.1. Analytical Problem
8.1.6.2. Introduction
8.1.6.3. Material and Methods
8.1.6.4. Questions
References
8.2. Spectroscopy
8.2.1. UV-VIS Spectroscopy, Project: Evaluation of Potential Saving through Use of Optimized Alloys
8.2.1.1. Analytical Problem
8.2.1.2. Introduction
8.2.1.3. Bandwidth
8.2.1.4. Material and Methods
8.2.1.5. Questions
References
8.2.2. Fourier-Transform Infrared Spectroscopy (FTIR), Project: Benchmarking with a New Competitive Japanese Product
8.2.2.1. Analytical Problem
8.2.2.2. Introduction
8.2.2.3. Material and Methods
8.2.2.4. Questions
References
8.2.3. Near-Infrared (NIR) Spectrometry, Project: Accelerated Raw Material Intake Control
8.2.3.1. Analytical Problem
8.2.3.2. Introduction
8.2.3.3. Material and Methods
8.2.3.4. Questions
Reference
8.2.4. Atomic Absorption Spectroscopy (AAS), Project: Recycling of Sewage Sludge in Agriculture
8.2.4.1. Analytical Problem
8.2.4.2. Introduction
8.2.4.3. Material and Methods
8.2.4.4. Questions
References
8.3. Electrophoretic Separation Methods
8.3.1. Capillary Electrophoresis, Project: Preservatives in Cosmetics: Friend or Foe
8.3.1.1. Analytical Problem
8.3.1.2. Introduction
8.3.1.3. Material and Methods
8.3.1.4. Questions
References
8.4. Automation
8.4.1. Flow Injection Analysis (FIA), Project: Phenol-like Flavor in Beer: a Quality Parameter to be Mastered
8.4.1.1. Analytical Problem
8.4.1.2. Introduction
8.4.1.3. Material and Methods
8.4.1.4. Questions
References
8.5. Mass Analytical Determination Methods
8.5.1. Karl Fischer Water Determination, Project: Water Content as a Quality Parameter
8.5.1.1. Analytical Problem
8.5.1.2. Introduction
8.5.1.3. Material and Methods
8.5.1.4. Questions
References
8.6. General Analytical Methods
8.6.1. Nitrogen and Protein Determination according to Kjeldahl, Project: Official Control at the Swiss Alps Dairy Ltd
8.6.1.1. Analytical Problem
8.6.1.2. Introduction
8.6.1.3. Material and Methods
8.6.1.4. Questions
References
8.6.2. Determination of Dissolved Oxygen (DO), Project: Monitoring the Efficiency of the Biological Stage in a Sewage Treatment Plant
8.6.2.1. Analytical Problem
8.6.2.2. Introduction
8.6.2.3. Material and Methods
8.6.2.4. Questions
References
8.7. Universal Separation Methods
8.7.1. Field Flow Fractionation (FFF), Project: Characterization of Nanoparticles
8.7.1.1. Analytical Problem
8.7.1.2. Introduction
8.7.1.3. Material and Methods
8.7.1.4. Questions
References
Appendix A Selection of Recommended Sources by Subject Area.
Note continued: Appendix B Statistical Tables
Appendix C Obligatory Declaration for Students
Appendix D International System of Units (SI)-and the New SI
Appendix E Evaluation Guide for Formal Reports
Appendix F Safety in the Analytical Laboratory.