Reactive drug metabolites /
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largestpharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concept...
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| Format: | eBook |
| Language: | English |
| Published: |
Weinheim :
Wiley-VCH,
©2012.
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| Series: | Methods and principles in medicinal chemistry ;
55. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
| Summary: | Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largestpharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the st. |
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| Physical Description: | 1 online resource (xvi, 385 pages) : illustrations |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 9783527655779 3527655778 9783527655748 3527655743 9781283604024 1283604027 9783527655762 352765576X 9783527655755 3527655751 |