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160302s2016 enk ob 001 0 eng |
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|a 9781118683859
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|2 bisacsh
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|1 https://id.oclc.org/worldcat/ddc/E3CYP9wFxfBFdj8Rd6PVggBQBm
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| 100 |
1 |
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|a Gribble, Gordon W.
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| 245 |
1 |
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|a Indole ring synthesis :
|b from natural products to drug discovery /
|c Gordon Gribble.
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| 264 |
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1 |
|a Chichester, West Sussex :
|b Wiley,
|c 2016.
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| 300 |
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|a 1 online resource
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 504 |
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|a Includes bibliographical references and index.
|
| 588 |
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|a Print version record and CIP data provided by publisher.
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| 520 |
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|a Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade - highlighted by the power of transition metal catalysis - this authoritative guide addresses the need for a comprehensive presentation of the myriad of methods for constructing the indole ring, from the ancient to the modern, and from the obscure to the well-known. Following presentation of the classic indole ring syntheses and many newer methods, coverage continues with indole ring syntheses via pyrroles, indolines, oxindoles, isatins, radical and photochemical reactions, aryne cycloadditions. This extensive volume concludes with the modern transition metal-catalyzed indole ring syntheses that utilize copper, palladium, rhodium, gold, ruthenium, platinum, and other metals to fashion the indole ring Indole Ring Synthesis is a comprehensive, authoritative and up-to-date guide to the synthesis of this important heterocycle for organic chemists, pharmaceutical researchers and those interested in the chemistry of natural products.
|
| 505 |
0 |
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|6 880-01
|a Intro; Title Page ; Copyright Page; About the Author ; Preface ; Contents; Chapter 1 Introduction; PART I Sigmatropic Rearrangements; PART II Nucleophilic Cyclization ; PART III Electrophilic Cyclization; PART IV Reductive Cyclization; PART V Oxidative Cyclization ; PART VI Radical Cyclization; PART VII Cycloaddition and Electrocyclization; PART VIII Indoles from Pyrroles; PART IX Indoles from Indolines; PART X Metal-Catalyzed Indole Synthesis ; PART XI Miscellaneous; Index; EULA; 1.1 Preview; 1.2 Indole-Containing Natural Products ; 1.3 Biological Activity of Indoles.
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| 505 |
8 |
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|a 1.4 Indole-Containing Pharmaceuticals 1.5 Indole-Containing Materials ; 1.6 Indole-Containing Ligands ; 1.7 Reviews of Indole-Ring Synthesis; References; Chapter 2 Fischer Indole Synthesis; Chapter 3 Gassman Indole Synthesis; Chapter 4 Bartoli Indole Synthesis; Chapter 5 Thyagarajan Indole Synthesis; Chapter 6 Julia Indole Synthesis; Chapter 7 Miscellaneous Sigmatropic Rearrangements; Chapter 8 Madelung Indole Synthesis; Chapter 9 Wittig-Madelung Indole Synthesis; Chapter 10 Jones-Schmid Indole Synthesis; Chapter 11 Couture Indole Synthesis; Chapter 12 Wender Indole Synthesis.
|
| 505 |
8 |
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|a Chapter 13 Smith Indole SynthesisChapter 14 Kihara Indole Synthesis; Chapter 15 Nenitzescu 5-Hydroxyindole Synthesis ; Chapter 16 Engler-Kita Indole Synthesis ; Chapter 17 Bailey-Liebeskind-O'Shea Indoline-Indole Synthesis; Chapter 18 Wright Indoline Synthesis; Chapter 19 Saegusa Indole Synthesis; Chapter 20 Ichikawa Indole Synthesis; Chapter 21 Miscellaneous Nucleophilic Cyclizations that Form the Indole Ring; Chapter 22 Sugasawa Indole Synthesis; Chapter 23 Bischler Indole Synthesis; Chapter 24 The Nordlander Indole Synthesis; Chapter 25 Nitrene Cyclization.
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| 505 |
8 |
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|a Chapter 40 Reissert Indole SynthesisChapter 41 Leimgruber-Batcho Indole Synthesis; Chapter 42 Pschorr-Hoppe Indole Synthesis; Chapter 43 Mąkosza Indole Synthesis; Chapter 44 Rawal Indole Synthesis; Chapter 45 The Baeyer-Jackson Indole Synthesis and Miscellaneous Reductive Cyclization Indole Syntheses; Chapter 46 Watanabe Indole Synthesis; Chapter 47 Knölker Carbazole Synthesis; Chapter 48 Miscellaneous Oxidative Cyclizations; Chapter 49 Fukuyama Indole Synthesis; Chapter 50 Other Tin-Mediated Indole Syntheses ; Chapter 51 The Murphy Indole Synthesis.
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| 650 |
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|a Organic compounds
|x Synthesis.
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| 650 |
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0 |
|a Indole.
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| 650 |
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0 |
|a Ring formation (Chemistry)
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| 650 |
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|a Transition metal catalysts.
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| 655 |
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|a Electronic books.
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| 776 |
0 |
8 |
|i Print version:
|a Gribble, Gordon W.
|t Indole ring synthesis.
|d Chichester, West Sussex : John Wiley & Sons, Inc., 2016
|z 9780470512180
|w (DLC) 2016007851
|
| 856 |
4 |
0 |
|u http://proxy.library.tamu.edu/login?url=https://onlinelibrary.wiley.com/book/10.1002/9781118695692
|z Connect to the full text of this electronic book
|t 0
|
| 880 |
0 |
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|6 505-01
|a 1 Introduction 1; 1.1 Preview 1; 1.2 Indole-Containing Natural Products 1; 1.3 Biological Activity of Indoles 4; 1.4 Indole-Containing Pharmaceuticals 15; 1.5 Indole-Containing Materials 21; 1.6 Indole-Containing Ligands 28; 1.7 Reviews of Indole-Ring Synthesis 32; 1.7.1 General Reviews on Indole Ring Synthesis 32; 1.7.2 Specialized Reviews 32; 1.7.3 Name Reactions 33; 1.7.4 Miscellaneous Reviews 33; 1.7.5 Synthesis of Carbazoles, Carbolines, and Indolocarbazoles 34; 1.7.6 Reviews of Indole Analogues 34; References 34; PART I Sigmatropic Rearrangements 39; 2 Fischer Indole Synthesis 41; 2.1 Preview 41; 2.2 Methods 41; 2.2.1 Traditional Methods 41; 2.2.2 Metal-Catalyzed Methods 44; 2.2.3 Solid-Phase Fischer Indolization Method 56; 2.2.4 Other General Methods 57; 2.2.5 Hydrazones 63; 2.2.6 Other Variations of Fischer Indole Synthesis 66; 2.3 Applications of Fischer Indolizations 68; 2.3.1 Drug Targets 68; 2.3.2 Natural Products 82; 2.3.3 Materials 97; 2.3.4 General 98; References 108; 3 Gassman Indole Synthesis 116; 4 Bartoli Indole Synthesis 121; 5 Thyagarajan Indole Synthesis 131; 6 Julia Indole Synthesis 137; 7 Miscellaneous Sigmatropic Rearrangements 139; PART II Nucleophilic Cyclization 145; 8 Madelung Indole Synthesis 147; 9 Wittig-Madelung Indole Synthesis 156; 10 Jones-Schmid Indole Synthesis 165; 11 Couture Indole Synthesis 174; 12 Wender Indole Synthesis 176; 13 Smith Indole Synthesis 181; 14 Kihara Indole Synthesis 186; 15 Nenitzescu 5-Hydroxyindole Synthesis 188; 16 Engler-Kita Indole Synthesis 206; 17 Bailey-Liebeskind-O'Shea Indoline-Indole Synthesis 213; 18 Wright Indoline Synthesis 219; 19 Saegusa Indole Synthesis 221; 20 Ichikawa Indole Synthesis 228; 21 Miscellaneous Nucleophilic Cyclizations that Form the Indole Ring 230; 22 Sugasawa Indole Synthesis 244; PART III Electrophilic Cyclization 247; 23 Bischler Indole Synthesis 249; 24 The Nordlander Indole Synthesis 260; 25 Nitrene Cyclization 264; 26 Cadogan-Sundberg Indole Synthesis 266; 27 Sundberg Indole Synthesis 278; 28 Hemetsberger Indole Synthesis 287; 29 Taber Indole Synthesis 296; 30 Knochel Indole Synthesis 299; 31 Täuber Carbazole Synthesis 301; 32 Quéguiner Azacarbazole Synthesis 304; 33 Iwao Indole Synthesis 307; 34 Hewson Indole Synthesis 309; 35 Magnus Indole Synthesis 310; 36 Feldman Indole Synthesis 311; 37 Butin Indole Synthesis 313; 38 Miscellaneous Electrophilic Cyclizations 317; PART IV Reductive Cyclization 323; 39 Nenitzescu o, β-Dinitrostyrene Reductive Cyclization 325; 40 Reissert Indole Synthesis 332; 41 Leimgruber-Batcho Indole Synthesis 338; 42 Pschorr-Hoppe Indole Synthesis 349; 43 Mąkosza Indole Synthesis 354; 44 Rawal Indole Synthesis 361; 45 The Baeyer-Jackson Indole Synthesis and Miscellaneous Reductive Cyclization Indole Syntheses 363; PART V Oxidative Cyclization 381; 46 Watanabe Indole Synthesis 383; 47 Knölker Carbazole Synthesis 391; 48 Miscellaneous Oxidative Cyclizations 396; PART VI Radical Cyclization 403; 49 Fukuyama Indole Synthesis 405; 50 Other Tin-Mediated Indole Syntheses 409; 51 The Murphy Indole Synthesis 412; 52 Miscellaneous Radical-Promoted Indole Syntheses 414; 53 The Graebe-Ullmann Carbazole-Carboline Synthesis 424; PART VII Cycloaddition and Electrocyclization 435; 54 Diels-Alder Cycloaddition 437; 55 Plieninger Indole Synthesis 464; 56 Photochemical Synthesis of Indoles and Carbazoles 468; 57 Dipolar Cycloaddition, Anionic, and Electrocyclization Reactions 483; PART VIII Indoles from Pyrroles 493; 58 Electrophilic Cyclization of Pyrrole 495; 59 Palladium-Catalyzed Cyclization of Pyrroles 503; 60 Cycloaddition Syntheses from Vinyl Pyrroles 506; 61 Electrocyclization of Pyrroles 512; 62 Indoles from Pyrrolo-2,3-Quinodimethanes 517; 63 Indoles via Dehydrogenation of Pyrroles 520; 64 Miscellaneous Indole Syntheses from Pyrroles 525; 65 Indoles via Arynes 528; PART IX Indoles from Indolines 537; 66 Indoline Dehydrogenation 539; 67 Indolines to Indoles by Functionalized Elimination 553; 68 Indolines from Oxindoles, Isatins, and Indoxyls 558; PART X Metal-Catalyzed Indole Synthesis 573; 69 Copper-Catalyzed Indole Synthesis 575; 70 Palladium-Catalyzed Indole Ring Synthesis: Hegedus 588; 71 Palladium-Catalyzed Indole Ring Synthesis: Mori-Ban-Heck 592; 72 Palladium-Catalyzed Indole Ring Synthesis: Aryl-Heck 597; 73 Palladium-Catalyzed Indole Ring Synthesis: Oxidative Cyclization 600; 74 Palladium-Catalyzed Indole Ring Synthesis: Watanabe-Cenini-Söderberg 604; 75 Palladium-Catalyzed Indole Ring Synthesis: Yamanaka-Sakamoto-Sonogashira 607; 76 Palladium-Catalyzed Indole Ring Synthesis: Larock 611; 77 Palladium-Catalyzed Indole Ring Synthesis: Cacchi 615; 78 Palladium-Catalyzed Indole Ring Synthesis: Buchwald-Hartwig 619; 79 Palladium-Catalyzed Indole Ring Synthesis: Miscellaneous 623; 80 Rhodium-Catalyzed Indole Ring Synthesis 632; 81 Gold-Catalyzed Indole Ring Synthesis 640; 82 Ruthenium-Catalyzed Indole Ring Synthesis 645; 83 Platinum-Catalyzed Indole Ring Synthesis 648; 84 Silver- and Zinc-Catalyzed Indole Ring Synthesis 651; 85 Iron-, Iridium-, and Indium-Catalyzed Indole Ring Syntheses 655; 86 Nickel-, Cobalt-, and Molybdenum-Catalyzed Indole Ring Syntheses 660; 87 Mercury- and Chromium-Catalyzed Indole Ring Syntheses 663; 88 Miscellaneous Metal-Catalyzed Indole Ring Syntheses 666; PART XI Miscellaneous 669; 89 Miscellaneous Indole Ring Syntheses 671; Index 676
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|b College Station
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| 998 |
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|a QD400.5.S95 G75 2016
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