Diversity-oriented synthesis : basics and applications in organic synthesis, drug discovery, and chemical biology /
"This book overviews diversity-oriented synthesis (DOS), one of the leading and dynamic topics in organic chemistry and drug discovery"--
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| Format: | eBook |
| Language: | English |
| Language Notes: | English. |
| Published: |
Hoboken, New Jersey :
Wiley,
[2013]
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| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- The basics of diversity-oriented synthesis
- Strategies applications of Multicomponent Reactions (MCRs) to diversity-oriented synthesis
- Cycloaddition reactions in diversity-oriented synthesis
- Phosphine organocatalysis as the platform for diversity-oriented synthesis
- Domino reactions in library synthesis
- Diversity-oriented synthesis of amino acid-derived scaffolds and peptidomimetics: a perspective
- Solid-phase synthesis enabling chemical diversity
- Macrocycles as templates for diversity generation in drug discovery
- Diversity-oriented synthesis of natural product-like libraries
- Chemoinformatic characterization of the chemical space and molecular diversity of compound libraries
- DNA-encoded chemical libraries
- Experimental approaches for rapid identification, profiling, and characterization of specific biological effects of Diversity-Oriented Synthesis compounds
- Small-molecule microarrays
- Yeast as a model in high-throughput screening of small molecule libraries
- Virtual screening methods
- Structure-activity relationship data analysis: activity landscapes and activity cliffs
- Diversity-oriented synthesis and drug development: facilitating the discovery of novel probes and therapeutics
- DOS-derived small-molecule probes in chemical biology.