Clinical diabetes research : methods and techniques /

A practical "how to" guide for multiple methods in metabolism, with a critical and objective discussion of strengths, limitations, and appropriate applications of the described methods. Edited by the winner of the Oskar-Minkowski Prize of the EASD in 2006. Clinical trials in populations at...

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Bibliographic Details
Other Authors: Roden, Michael, Dr
Format: eBook
Language:English
Published: Chichester, West Sussex, England ; Hoboken, NJ : John Wiley & Sons, ©2007.
Subjects:
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Basics of clinical metabolic research
  • Methods for the assessment of ß-cell function in vivo
  • Assessment of insulin sensitivity from steady-state and dynamic tests
  • Glucose clamp techniques
  • Methods of assessment of counterregulation to hypoglycaemia
  • Glucose kinetics: measurement of flux rates
  • Xenobiotics as probes of carbohydrate metabolism
  • Tracing hepatic glucose and glycogen fluxes with ²H₂O
  • Lipid kinetics
  • Protein and amino acid kinetics
  • Assessment of metabolic fluxes by in vivo MR spectroscopy
  • Positron emission tomography in metabolic research
  • Assessment of body fact content and distribution
  • Tissue biopsies in diabetes research
  • Assessment of vascular function
  • Cardiovascular autonomic function testing
  • Nerve function testing
  • Kidney function
  • Techniques for the investigation of the eye in diabetes
  • Basics of molecular genetics: lessons from type 2 diabetes
  • Good clinical practice: friend or foe?
  • Statistical considerations in diabetes trials.