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From first principles to real-world applications-here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume re.
DRUG DISCOVERY AND DEVELOPMENT; CONTENTS; Contributors; Preface; 17 Bioactive Molecules in Medicinal Plants: A Perspective on Their Therapeutic Action; 17.1 Introduction; 17.2 Evolutionary Relationships Among Plants and Humans; 17.3 Traditional Wisdom; 17.4 Unique Libraries for Plants; 17.5 Drugs and Bioactive Molecules from Plants; 17.6 Synergism in Herbal Formulations; 17.7 Interactions Between Modern Drugs and Natural Products; 17.8 Bioavailability and Bioefficacy Enhancers; 17.9 Combination Therapies in Modern Drugs; 17.10 Role of Developments in Technologies and Analytical Tools
17.10.1 Developments in Separation Technologies17.10.2 Developments in Combined Techniques and Advanced Technologies; 17.10.3 Molecular Farming and Bioengineering of Medicinal Plants; 17.10.4 High-Throughput Screening of Natural Products; 17.11 Herbal Medicine: The Best Possible Route to Health Care; References; 18 Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools; 18.1 Introduction; 18.2 Solid-Supported Reagents as Tools in Natural Product Synthesis; 18.3 Multistep Use of Supported Reagents in Natural Product Synthesis; 18.4 Conclusions
Description based upon print version of record.
23.1.2 Challenges in Developing and Scaling Up Chemical Processes.
References19 Insulin Sensitizers: Emerging Therapeutics; 19.1 Introduction; 19.2 Therapeutic Interventions; 19.3 Discovery of Insulin Sensitizers; 19.4 Journey Toward New Drugs; 19.5 Conclusions; References; 20 Criteria for Industrial Readiness of Chiral Catalysis Technology for the Synthesis of Pharmaceuticals; 20.1 Introduction; 20.2 Criteria for Technology Readiness; 20.3 Examples of Industrially Ready Chiral Catalytic Technologies and Their Application; 20.3.1 Lipase Bioresolution: Ethyl 3-Amino-3-Phenylpropionate; 20.3.2 Aminoacylase Bioresolution of N-Acylamino Acids.
Includes bibliographical references and index.