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Nanofluidics /

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Bibliographic Details
Corporate Author: Knovel (Firm)
Other Authors: Edel, Joshua B. (Editor), Ivanov, Aleksandar C. (Editor), Kim, MinJun (Editor)
Format: eBook
Language:English
Published: Cambridge : Royal Society of Chemistry, 2016.
Cambridge : Royal soc of chemistry, 2016.
Edition:Second edition.
Series:RSC nanoscience & nanotechnology ; no. 40.
Subjects:
Fluidic devices.
Nanoelectromechanical systems.
Dispositifs fluidiques.
Nanosystèmes électromécaniques.
Fluidic devices
Nanoelectromechanical systems
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Machine generated contents note: chapter 1 Transport of Ions, DNA Polymers, and Microtubules in the Nanofluidic Regime / C. Dekker
  • 1.1. Introduction
  • 1.2. Ionic Transport
  • 1.2.1. Electrically Driven Ion Transport
  • 1.2.2. Streaming Currents
  • 1.2.3. Streaming Currents as a Probe of Charge Inversion
  • 1.2.4. Electrokinetic Energy Conversion in Nanofluidic Channels
  • 1.3. Polymer Transport
  • 1.3.1. Pressure-driven Polymer Transport
  • 1.3.2. Electrokinetic DNA Concentration in Nanofluidic Channels
  • 1.3.3. DNA Conformations and Dynamics in Slit-like Nanochannels
  • 1.4. Microtubule Transport in Nanofluidic Channels Driven by Electric Fields and by Kinesin Biomolecular Motors
  • 1.4.1. Electrical Manipulation of Kinesin-driven Microtubule Transport
  • 1.4.2. Mechanical Properties of Microtubules Measured from Electric Field-induced Bending
  • 1.4.3. Electrophoresis of Individual Microtubules in Microfluidic Channels
  • Acknowledgements
  • References.
  • Note continued: chapter 2 Electrokinetic Transport and Fluidic Manipulation in Three Dimensional Integrated Nanofluidic Networks / P.W. Bohn
  • 2.1. Introduction
  • 2.2. Experimental Characterization of Nanofluidic Flow
  • 2.2.1. Surface Charge
  • 2.2.2. Debye Length
  • 2.3. Integrated Nanofluidic Systems
  • 2.3.1. Molecular Sampling (Digital Fluidic Manipulation)
  • 2.3.2. Pre-concentration
  • 2.3.3. Chemical Reactivity
  • 2.4. Theory and Simulations
  • 2.4.1. Theory
  • 2.4.2. Ion Accumulation and Depletion
  • 2.4.3. Ionic Currents
  • 2.4.4. Induced Flow
  • 2.4.5. Nanofluidic Diode
  • 2.4.6. Reaction Kinetics
  • 2.5. Conclusions
  • Acknowledgements
  • References
  • chapter 3 Nanopillars, Nanowires and Nanoballs for DNA and Protein Analysis / Yoshinobu Baba
  • 3.1. Introduction
  • 3.2. Fabrication of Nanopillars, Nanowires, and Nanoballs
  • 3.2.1. Fabrication of Nanopillars
  • 3.2.2. Fabrication of Nanowires
  • 3.2.3. Self-assembled Nanospheres
  • 3.2.4. Synthesis of PEGylated-latex.
  • Note continued: 3.3. Nanopillars for DNA and Protein Analysis
  • 3.3.1. DNA Analysis by Tilted Patterned Nanopillar Chips
  • 3.3.2. Single DNA Molecule Imaging in Tilted Pattern Nanopillar Chips
  • 3.3.3. DNA Analysis by Square Patterned Nanopillar Chips and Nanowall Chips
  • 3.3.4. Single DNA Molecule Imaging in Square Patterned Nanopillar Chips
  • 3.3.5. Protein Analysis by Tilted Patterned Nanopillar Chips
  • 3.4. Nanowalls for DNA Analysis
  • 3.4.1. DNA Analysis by Nanowall Chips
  • 3.4.2. Single DNA Molecule Imaging in Nanowall Chips
  • 3.4.3. Mechanism of Separation in Nanopillar Chips and Nanowall Chips
  • 3.5. Nanowires for DNA and Protein Analysis
  • 3.5.1. DNA Analysis by Nanowire Chips
  • 3.5.2. Single DNA Molecule Imaging in Nanowire Chips
  • 3.5.3. Separation Mechanism in Nanowire Chips
  • 3.5.4. Protein Analysis by Nanowire Chips
  • 3.6. Nanoballs for DNA Analysis
  • 3.6.1. DNA Analysis by a Self-assembled Nanosphere Solution in a Chip.
  • Note continued: 3.6.2. DNA Analysis by PEGylated-latex Mixed Polymer Solution in a Chip
  • 3.6.3. Single DNA Molecule Imaging in a Nanoball Solution
  • 3.7. Conclusion
  • Acknowledgements
  • References
  • chapter 4 Nanofluidic Devices for Electroanalytical Applications / Binoy Paulose Nadappuram
  • 4.1. Introduction
  • 4.2. Nanofluidic Devices for Single Molecule Electrochemical Detection
  • 4.3. Nanofluidic Devices for Selective Electrochemical Detection
  • 4.4. Nanofluidic Devices for Probing Electron Transfer Kinetics
  • 4.5. Conclusions
  • References
  • chapter 5 Nanofluidic Strategies for Cancer Research / Mien-Chie Hung
  • 5.1. Introduction
  • 5.2. Fabrication of Nanofluidic Platforms
  • 5.2.1. Concepts
  • 5.2.2. Top-down Nanofluidic Platform Fabrication
  • 5.2.3. Nanofluidic Platform Fabrication
  • 5.2.4. Heat-induced Stretching Method
  • 5.3. Analysis of Single Molecules Using Nanofluidic Tubes
  • 5.3.1. Experimental Setup.
  • Note continued: 5.3.2. Detection and Measurement of Single Molecules in Nanofluidic Channels
  • 5.3.3. Electrokinetic Molecule Transport in Nanofluidic Tubing
  • 5.4. Cancer Research Application
  • 5.4.1. Determination of the Detection of the MAX Concentration Using a Nanochannel Device
  • 5.4.2. Epithelial Growth Factor Receptor Ubiquitination Detection by Microchannels with Two Fluorescent Color Detection System
  • 5.4.3. Electrokinetic C-3. EGFR Phosphorylation Detection by Microchannels with Three Fluorescent Color Detection System
  • 5.5. Conclusions
  • Acknowledgements
  • References
  • chapter 6 Nanofluidics for Biomolecular Detection / Masateru Taniguchi
  • 6.1. Introduction to Nanopore-based Genome Sequencing
  • 6.1.1. The Basic Idea: From Coulter Counter to Sequencer
  • 6.1.2. Sequencing via Tunnelling Conductance
  • 6.1.3. Challenges: Regulating Molecule Motion in Nanofluidics
  • 6.2. Electrical Gating of Nanopore System
  • 6.2.1. Electroosmotic Flow and DNA Motion.
  • Note continued: 6.2.2. Poisson
  • Navier
  • Nernst Description of Nanofluidic System
  • 6.2.3. Gate Manipulating: DNA Translocating Stage
  • 6.2.4. Gate Manipulating: DNA Capture Stage
  • 6.2.5. Experiments: Gating Nanopore
  • 6.3. Salt-gradient Driving DNA Motion
  • 6.3.1. DNA Capture Under Salt Gradient
  • 6.3.2. DNA Translocation Tuned by Salt Gradient
  • 6.4. Temperature-gradient for DNA Propelling
  • 6.4.1. Temperature Distribution in Nanofluidics
  • 6.4.2. Temperature-gradient Driven DNA Capture
  • 6.4.3. Temperature-gradient Driven DNA Translocation
  • References
  • chapter 7 Silicon Nitride Thin Films for Nanofluidic Device Fabrication / J.W. Nichols
  • 7.1. Introduction
  • 7.1.1. Formation of LPCVD Silicon Nitride Films
  • 7.1.2. Formation of Free-standing LPCVD Silicon Nitride Films
  • 7.1.3. Overview of Selected Free-standing Silicon Nitride Membrane Structural Motifs and Applications
  • 7.2. Nanofluidic Applications of Thin Silicon Nitride Membranes.
  • Note continued: 7.2.1.10 Picoleagues Under the Sea: Nanofluidics for Transmission Electron Microscopy (TEM) of Liquid Samples
  • 7.2.2. Portal to the Molecular World: Nanopore Single-molecule Sensing
  • 7.3. Silicon-rich Silicon Nitride Surface Chemistry
  • 7.3.1. Real-world Silicon Nitride Surface Chemistry
  • 7.3.2. Hydrosilylation of Silicon-rich Silicon Nitride
  • 7.4. Fabrication of Channels in Silicon Nitride Nanofluidic Devices
  • 7.4.1. Windowed Nanochannels
  • 7.4.2. Nanopore Formation and Fabrication
  • 7.5. Peering into the Void: Characterising Nanopores Using Conductance
  • 7.6. Nanofluidic Vistas
  • Acknowledgements
  • References
  • chapter 8 Single Molecule Protein Unfolding Using a Nanopore / MinJun Kim
  • 8.1. Introduction
  • 8.1.1. Nanopores as a Unique Molecular Probe
  • 8.2. Nanopore Geometry and Fabrication
  • 8.3. Protein Adsorption Kinetics
  • 8.3.1. The PDZ2 Protein Domain
  • 8.3.2. PDZ2-Nanopore Interactions.
  • Note continued: 8.3.3. Voltage Pulses for Controlling Nanopore Clogging
  • 8.4. Chemical and Electric Field Unfolding: Competing Effects
  • 8.5. Simulating Protein Folding in a Nanopore
  • 8.6. Detecting Single Point Mutations and Stability Variations
  • 8.6.1. Translocation Event Statistics
  • 8.6.2. Excluded Volumes and Stability Measurements
  • 8.7. Outlook
  • References
  • chapter 9 Low Noise Nanopore Platforms Optimised for the Synchronised Optical and Electrical Detection of Biomolecules / J.B. Edel
  • 9.1. Introduction
  • 9.2. Hybrid Nanopore
  • Zero-mode Waveguide Platforms: A Brief History
  • 9.3. Designing a Hybrid Nanopore-Zero-mode Waveguide
  • 9.3.1. Choice of Pore Diameter
  • 9.3.2. Choice of Membrane Materials
  • 9.4.A Novel Low-noise Platform
  • 9.4.1. Fabrication Protocol
  • 9.4.2. Laboratory Set-up
  • 9.4.3. Sources of Ionic Current Noise
  • 9.4.4. Device Performance
  • 9.5. Synchronizing Optical and Electrical Detection Measurements.
  • Note continued: 9.5.1. Independent Electrical and Optical Detection of dsDNA
  • 9.5.2. Synchronized Optical and Electrical Detection of dsDNA
  • 9.5.3. Future Work: Device Optimisation and Applications
  • 9.6. Conclusion
  • Acknowledgements
  • References.