rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Concepts and models for drug permeability studies
    sub title: cell and tissue based in vitro culture models
  name:
    name part: Sarmento, Bruno
    role:
      role term: editor.
  name:
    name part: Leite Pereira, Catarina
    role:
      role term: editor.
  name:
    name part: Neves, José Das
    role:
      role term: editor.
  name:
    name part: Knovel (Firm)
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: mau
    date issued: 2024
    edition: Second edition.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs. This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biological membranes, or animal/patient-derived tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how each model may provisionally resemble different drug absorption route. Chapters included in the first edition were updated with relevant data published in recent years, while four new chapters were included to reflect new emerging directions and trends in drug permeability models. Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, is a critical reference for drug discovery and drug formulation scientists interested in delivery systems intended for the administration of drugs through mucosal routes and other important tissue barriers (e.g. the BBB). Researchers studying mucosal biology can use this book to familiarize themselves and exploit the synergic effect of mucosal delivery systems and biomolecules.
  note: edited by Bruno Sarmento, Catarina Leite Pereira and José Das Neves.
  note: Includes index.
  subject:
    topic: Drugs
    topic: Testing
  subject:
    topic: Drugs
    topic: Physiological transport
    topic: Research
    topic: Methodology
  subject:
    topic: Pharmacokinetics
  subject:
    topic: Pharmacokinetics
  subject:
    topic: Médicaments
    topic: Essais cliniques
  subject:
    topic: Médicaments
    topic: Transport physiologique
    topic: Recherche
    topic: Méthodologie
  subject:
    topic: Pharmacocinétique
  classification: RM301.25
  classification: 615/.1901
  related item:
    title info:
      title: Woodhead Publishing series in biomedicine
  identifier: 9780443155109
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: OPELS
    record creation date: 240312
    record change date: 20251209192744.0
    record identifier: in00005672135
    language of cataloging:
      language term: eng