rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Parkinson's Disease: Insights into Novel Astrocyte-Mediated Mechanisms of Dopaminergic Neurodegeneration
  name:
    name part: Bancroft, Eric Andrew
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Srinivasan, Rahul
    role:
      role term: thesis advisor.
  name:
    name part: Texas A&M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2023
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: Parkinson's Disease (PD) is the second most common neurodegenerative disorder worldwide, with no known cure. The main pathological hallmark of PD is the loss of DA neurons within the substantia nigra pars compacta (SNc). The neurocentric approach to PD research has given us insight into intrinsic mechanisms by which DA neurons degenerate, however, considering the lack of therapeutic breakthroughs, it is imperative to consider the role that glia, particularly astrocytes, play in PD pathogenesis. Astrocytes are the most prominent cell type within the central nervous system (CNS) and were originally thought to only provide passive support for neurons. Emerging evidence has implicated astrocytes as an active contributor to CNS physiology via numerous mechanisms. One method by which astrocytes regulate brain activity is via the secretion of a plethora of molecules. While many of these molecules such as glutamate and ATP have known targets and cellular effects, it is important to consider the entirety of the astrocyte secretome and novel targets by which these molecules may modulate DA neuron physiology in the context of PD. Additionally, developing specific, targeted therapies for PD has been challenging because of the difficulty of drug delivery. Effective drug-delivery to the brain has been challenging due to the high selectivity of the blood-brain barrier (BBB), therefore it is also essential to develop novel methods, such as nanoparticles, to deliver therapeutic molecules across the BBB. In this dissertation, I focus on these barriers for developing novel PD treatments by understanding how pathological astrocyte-neuron interactions affect neurodegeneration and developing optimized drug delivery systems for targeted brain-region specific drug delivery. I specifically address these issues by: (i) Developing a primary midbrain astrocyte-neuron co-culture system to investigate astrocyte-neuron communication, (ii) Determine the effects of gold-coated superparamagnetic iro…
  note: by Eric Bancroft.
  note: "Major Subject: Medical Sciences"
  note: Includes vita.
  note: Doctor of Philosophy Texas A&M University 2022 https://hdl.handle.net/1969.1/198619
  note: Includes bibliographical references.
  note: Text (Dissertation)
  subject:
    topic: Major Medical Sciences
  subject:
    topic: Parkinson's disease
  subject:
    topic: Astrocytes
  subject:
    topic: S100B
  subject:
    topic: Voltage-gated ion channel
  subject:
    topic: Nanoparticles
  subject:
    topic: Neurodegeneration
  subject:
    topic: Dopamine
  identifier: https://hdl.handle.net/1969.1/198619
  record info:
    record content source: TXA
    record creation date: 241022
    record change date: 20250326141437.8
    record identifier: in00005621453
    language of cataloging:
      language term: eng