rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: The
    title: Influence of Calcium Propionate on Regulating Physical Activity
  name:
    name part: Breidenbach, Brianne Marie
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Lightfoot, Timothy
    role:
      role term: thesis advisor.
  name:
    name part: Texas A&M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2023
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: The short-chain fatty acid propionate is a commonly used food preservative and mold inhibitor and is produced endogenously by the gut microbiota. Although generally recognized as safe, it's possible contribution to neurodevelopmental disorders and mixed results related to diabetes and obesity metabolism have called the safety of the compound into question. While there is a strong indication supporting the involvement of short chain fatty acids (SCFAs) in exercise performance, it is currently unknown if calcium propionate (CaP) consumption will influence mechanisms driving voluntary physical activity levels. As such, the primary purpose of this dissertation was to determine the following: (1a) whether prenatal dietary calcium propionate affected voluntary wheel running; (1b) to determine the mechanisms by which calcium propionate alters voluntary wheel running. Secondary outcomes were to determine whether a 0.3% CaP diet would: (2a) alter fecal and circulating SCFAs; (2b) alter dopaminergic signaling in the nucleus accumbens; or (2c) alter GPR43/41 expression in the muscle. Methods consisted of wheel running, diet and drug interventions, gas-chromatography-mass spectrometry, and western blotting. Our results indicated that a 0.3% CaP diet did not significantly alter body composition or wheel running. Drug treatments utilizing a SCFA receptor antagonist did not reveal any differences in wheel running. Furthermore, no significant differences were detected in plasma or fecal propionate concentrations. These results indicate that the 0.3% CaP diet was insufficient at increasing systemic propionate to levels high enough to elicit changes on behavior or body composition. The CaP diet did not significantly alter DRD1 or TH protein expression in males or females; however, the treatment did significantly increase ERK ½ abundance in the nucleus accumbens of male mice and lower GPR43 receptor abundance in the gastrocnemius muscle of female mice. The alteration in muscle was mos…
  note: by Brianne Breidenbach.
  note: "Major Subject: Kinesiology"
  note: Includes vita.
  note: Doctor of Philosophy Texas A&M University 2022 https://hdl.handle.net/1969.1/198468
  note: Includes bibliographical references.
  note: Text (Dissertation)
  subject:
    topic: Major Kinesiology
  subject:
    topic: Physical activity
  subject:
    topic: calcium propionate
  subject:
    topic: wheel running
  identifier: https://hdl.handle.net/1969.1/198468
  record info:
    record content source: TXA
    record creation date: 240924
    record change date: 20250326141428.0
    record identifier: in00005621199
    language of cataloging:
      language term: eng