rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Explorations in Parkinson's Disease: A Systematic Examination of Aging Astrocyte Endfoot Calcium Dysregulation and Sex Specific Barriers in Developing Neuroprotective Treatments
  name:
    name part: Zarate, Sara Marie
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Srinivasan, Rahul
    role:
      role term: thesis advisor.
  name:
    name part: Texas A&M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2023
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: Parkinson's disease is a multifaceted neurodegenerative disease characterized by dopamine neuron loss; but more importantly there are no know treatments for PD that can truly alter disease progression. The two major risk factors for PD are advanced age and male sex. It is in these risk factors that the key to developing effective neuroprotective drugs for men and women lies. To date, nearly all other age-related neurodegenerative diseases coincide with major changes to the blood brain barrier and brain vasculature in general. Astrocytes are one of the most numerous cells in the brain and regulate the BBB but remain critically under researched in health, aging, and disease. In this dissertation, I developed a model to study astrocyte endfoot Ca2+ signals across the lifespan to determine the extent to which endfoot Ca2+ events are altered by aging and most importantly in which stage of life these changes occur. Sex differences exist in every aspect of PD from disease susceptibility, severity, treatment efficacy. The basis for these differences likely lies in the baseline sex specific regulatory mechanisms within the nigrostriatal pathway. To address these points, I (i) developed a robust model of PD using a unilateral striatal lesion in male and female mice to test the neuroprotective effects of cytisine a smoking cessation drug and (ii) developed a model of surgical menopause prior to striatal lesion to further characterize the role of estrogen induce neuroprotection in PD. The electronic version of this dissertation is accessible from https://hdl.handle.net/1969.1/198670
  note: by Sara Zarate.
  note: "Major Subject: Medical Sciences"
  note: Includes vita.
  note: Doctor of Philosophy Texas A&M University 2022 https://hdl.handle.net/1969.1/198670
  note: Includes bibliographical references.
  note: Text (Dissertation)
  subject:
    topic: Major Medical Sciences
  subject:
    topic: parkinson's disease
  subject:
    topic: sex differences
  subject:
    topic: aging
  subject:
    topic: astrocytes
  subject:
    topic: nAChR
  identifier: https://hdl.handle.net/1969.1/198670
  record info:
    record content source: TXA
    record creation date: 241105
    record change date: 20250326141425.9
    record identifier: in00005621159
    language of cataloging:
      language term: eng