3D printing of pharmaceutical and drug delivery devices : progress from bench to bedside /

"Three-dimensional printing (3DP) also known as Additive Manufacturing (AM) has emerged as exciting technology for the manufacture of pharmaceutical products for personalised patient treatment. The interindividual variability of the human population is a constant challenge when striving for eff...

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Bibliographic Details
Corporate Author: Knovel (Firm)
Other Authors: Lamprou, Dimitrios (Editor), Douroumis, Dennis (Editor), Qi, Sheng (Researcher in pharmaceutics) (Editor)
Format: eBook
Language:English
Published: Hoboken, NJ : John Wiley & Sons Inc., 2024.
Series:Advances in pharmaceutical technology.
Subjects:
Online Access:Connect to the full text of this electronic book

MARC

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245 0 0 |a 3D printing of pharmaceutical and drug delivery devices :  |b progress from bench to bedside /  |c edited by Dimitrios A. Lamprou, Queen's University Belfast, Liburn Road, Belfast, United Kingdom, Dennis Douroumis, School of Science, University of Greenwich, Medway Campus, Central Avenue, Chatham Maritime, United Kingdom, Sheng Qi, University of East Anglia, Norwich Research Park, United Kingdom. 
246 3 |a Three-dimensional printing of pharmaceutical and drug delivery devices 
264 1 |a Hoboken, NJ :  |b John Wiley & Sons Inc.,  |c 2024. 
264 4 |c ©2024 
300 |a 1 online resource (239 variously numbered pages) :  |b illustrations (chiefly color). 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a Advances in pharmaceutical technology 
504 |a Includes bibliographical references and index. 
520 |a "Three-dimensional printing (3DP) also known as Additive Manufacturing (AM) has emerged as exciting technology for the manufacture of pharmaceutical products for personalised patient treatment. The interindividual variability of the human population is a constant challenge when striving for effective drug delivery because patients come in different shapes, sizes, ages, genetics and necessities and so require medication personalised to their needs for the most effective outcomes [1] [2]. 3DP has been shown to be a flexible technique which can be used to manufacture drug delivery devices (DDD) for a wide array of applications such as tablets, implants, microneedles and suppositories [3-5]. In addition, compared to conventional large scale production techniques, such as tablet pressing, 3DP is much more agile with the potential to simplify supply chains and accelerate development cycles. Such traits, make 3DP an ideal candidate technology to produce on-demand personalized medicines and in turn, improve patient quality of life. However, there are still several challenges hindering its adoption. Limited availability of biocompatible materials, the incompatibility of the API and or polymer with the printing conditions and regulatory hurdles presents a significant challenge when designing 3DP pharmaceutical products. This is highlighted by the presence of just one 3DP pharmaceutical product currently on the market, Spritam® [6]. Material choice is a fundamental consideration when designing a pharmaceutical dosage form. All drug products are comprised of an active pharmaceutical ingredient (API) which is the bioactive component and inactive functional excipients which facilitate the release of the API to the target location in the body. With the advance of 3D printing medicine, API carrier materials have an increasingly important role in not only protecting the API in a convenient printable package and disguising unpalatable ingredients but also in facilitating complex release profiles. Several 3D printing techniques are applicable for manufacturing DDD: Thermal Extrusion-based deposition systems (TE), Semi-solid extrusion (SSE), Stereolithography (SLA) and Powder Bed fusion (PBF). Successful printing of pharmaceuticals requires consideration of the nature of the 3D printing process. Each technique has its own benefits and limitations in terms of material compatibility, print quality and scalability and so must be considered as a whole when designing a new DDD. The objective of this book chapter is to first discuss each printing technique exploring the key material characteristics and processing parameters that influence both printability and drug delivery performance. Subsequently, the materials which have shown suitability for 3DP manufacture of DDD will be discussed with a focus on the key material attributes relevant for printing and drug release properties"--  |c Provided by publisher. 
588 |a Description based on online resource; title from digital title page (viewed on May 22, 2024). 
650 0 |a Drug delivery devices. 
650 0 |a Three-dimensional printing. 
650 0 |a Pharmaceutical technology. 
650 2 |a Printing, Three-Dimensional 
650 2 |a Technology, Pharmaceutical 
650 6 |a Médicaments  |x Administration  |x Dispositifs. 
650 6 |a Impression tridimensionnelle. 
650 6 |a Techniques pharmaceutiques. 
650 7 |a 3-D printing.  |2 aat 
650 7 |a Industrial & Technical.  |2 bisacsh/2022 
650 7 |a Chemistry.  |2 bisacsh/2022 
650 7 |a SCIENCE.  |2 bisacsh/2022 
650 7 |a Drug delivery devices  |2 fast 
650 7 |a Pharmaceutical technology  |2 fast 
650 7 |a Three-dimensional printing  |2 fast 
655 7 |a Electronic books.  |2 local 
700 1 |a Lamprou, Dimitrios,  |e editor. 
700 1 |a Douroumis, Dennis,  |e editor.  |1 https://id.oclc.org/worldcat/entity/E39PCjCkPJVv7c9gGdpc8QqVcq 
700 1 |a Qi, Sheng  |c (Researcher in pharmaceutics),  |e editor. 
710 2 |a Knovel (Firm) 
776 0 8 |i Print version:  |t 3D printing of pharmaceutical and drug delivery devices  |d Hoboken, NJ : John Wiley & Sons Ltd, 2023  |z 9781119835974  |w (DLC) 2023021776 
830 0 |a Advances in pharmaceutical technology. 
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