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Handbook of nuclear medicine and molecular imaging for physicists
Modelling, dosimetry and radiation protection
Mathematical modelling is an important part of nuclear medicine. Therefore, several chapters of this book have been dedicated towards describing this topic. In these chapters, an emphasis has been put on describing the mathematical modelling of the radiation transport of photons and electrons, as well as on the transportation of radiopharmaceuticals between different organs and compartments. It also includes computer models of patient dosimetry. Two chapters of this book are devoted towards introducing the concept of biostatistics and radiobiology. These chapters are followed by chapters detailing dosimetry procedures commonly used in the context of diagnostic imaging, as well as patient-specific dosimetry for radiotherapy treatments. For safety reasons, many of the methods used in nuclear medicine and molecular imaging are tightly regulated. Therefore, this volume also highlights the basic principles for radiation protection. It discusses the process of how guidelines and regulations aimed at minimizing radiation exposure are determined and implemented by international organisations. Finally, this book describes how different dosimetry methods may be utilized depending on the intended target, including whole-body or organ-specific imaging, as well as small-scale to cellular dosimetry. This text will be an invaluable resource for libraries, institutions, and clinical and academic medical physicists searching for a complete account of what defines nuclear medicine. The most comprehensive reference available providing a state-of-the-art overview of the field of nuclear medicine Edited by a leader in the field, with contributions from a team of experienced medical physicists, chemists, engineers, scientists, and clinical medical personnel Includes the latest practical research in the field, in addition to explaining fundamental theory and the field's history
1. Introduction to Biostatistics Johan Gustafsson and Markus Nilsson2. Radiobiology Lidia Strigari and Marta Cremonesi3. Diagnostic Dosimetry Lennart Johansson and Martin Andersson4. Time-Activity Curves: Data, Models, Curve Fitting and Model Selection Gerhard Glatting5. Tracer Kinetic Modelling and its use in PET Quantification Mark Lubberink and Michel Koole6. Principles of Radiological Protection in Healthcare S©œren Mattsson7. Controversies in Nuclear Medicine Dosimetry Michael G. Stabin8. Monte Carlo Simulation of Photon and Electron Transport in Matter Jos©♭ M. Fern©Łndez-Varea9. Patient Models for Dosimetry Applications Michael G. Stabin10. Patient-Specific Dosimetry Calculations Manuel Bardi©♭s, Naomi Clayton, Gunjan Kayal and Alex Vergara Gil11. Whole Body Dosimetry Jonathan Gear12. Personalized Dosimetry in Radioembolization Remco Bastiaannet and Hugo W.A.M. de Jong13. Thyroid Imaging and Dosimetry Michael Lassmann and Heribert H©Þnscheid14. Bone Marrow Dosimetry Cecilia Hindorf15. Cellular and Multicellular Dosimetry Roger W. Howell16. Alpha-Particle Dosimetry Stig Palm17. Staff Radiation Protection Lena Jnsson18. IAEA support to Nuclear Medicine Gian Luca Poli
Michael Ljungberg is a Professor at Medical Radiation Physics, Lund, Lund University, Sweden. He started his research in the Monte Carlo field in 1983 through a project involving a simulation of whole-body counters but later changed the focus to more general applications in nuclear medicine imaging and SPECT. As a parallel to his development of the Monte Carlo code SIMIND, he started working in 1985 with quantitative SPECT and problems related to attenuation and scatter. After obtaining his PhD in 1990, he received a research assistant position that allowed him to continue developing SIMIND for quantitative SPECT applications and establish successful collaborations with international research groups. At this time, the SIMIND program also became used world-wide. Dr. Ljungberg later became an associate professor in 1994 and he received, after a couple of years working clinically as a nuclear medicine medical physicist, a full professorship in the Science Faculty at Lund University in 2005. He became the Head of the Department of Medical Radiation Physics at Lund University in 2013 and a full professor in the Medical Faculty at Lund University in 2015. Beside from the development of SIMIND to include also new camera system such as CZT detectors, his research includes an extensive project in oncological nuclear medicine, where he, with colleagues, develop dosimetry methods based on quantitative SPECT, Monte-Carlo absorbed dose calculations, and methods for accurate 3D dose planning for internal radionuclide therapy. During the recent years, his has been focused on implementing Monte-Carlo based image reconstruction in SIMIND. He is also involved in the undergraduate education of medical physicists and bio-medical engineers and are supervising MSc and PhD students. In 2012, Professor Ljungberg became a member of the European Association of Nuclear Medicines task group on Dosimetry and served there for six years. He has published over 100 original papers, 18 conference proceedings, 18 books and book chapters and 14 peer-reviewed review papers.
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