Predicting solubility of new drugs : handbook of critically curated data for pharmaceutical research /
"In pharmaceutical research, solubility plays a key part in the assessment of pharmacokinetic risks. Poor drug absorption, reduced efficacy, excessive metabolism and adverse reactions are frequently related to issues of drug solubility. During early discovery research at pharmaceutical companie...
| Main Author: | |
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| Format: | eBook |
| Language: | English |
| Published: |
Boca Raton :
CRC Press,
[2024]
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| Edition: | First edition. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book. |
| Summary: | "In pharmaceutical research, solubility plays a key part in the assessment of pharmacokinetic risks. Poor drug absorption, reduced efficacy, excessive metabolism and adverse reactions are frequently related to issues of drug solubility. During early discovery research at pharmaceutical companies, many thousands of molecules are considered. Most are rejected due to perceived unfavorable properties. Here the author uses the so-called Wiki-pS0TM database which forms the backbone of this unique handbook. Also discussed is the emerging class of therapeutically-promising research molecules called PROTACs (proteolysis-targeting chimeras), showing a propensity for 'undruggable' targets"-- |
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| Physical Description: | 1 online resource : illustrations. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 9781032625256 1032625252 9781003826323 1003826326 9781003826316 1003826318 |