Library design, search methods, and applications of fragment-based drug design /

Bibliographic Details
Corporate Authors:	American Chemical Society. Division of Chemical Information, American Chemical Society. Division of Computers in Chemistry
Other Authors:	Bienstock, Rachelle J.
Format:	eBook
Language:	English
Language Notes:	English.
Published:	Washington, DC : American Chemical Society, ©2011.
Series:	ACS symposium series ; 1076.
Subjects:	Drugs > Design. Pharmaceutical chemistry. Pharmaceutical technology. Pharmacology. Chemistry. Physical sciences. Life sciences. Methodology. Investigative Techniques Laboratory Chemicals Chemistry, Pharmaceutical Technology, Pharmaceutical Analytical, Diagnostic and Therapeutic Techniques and Equipment Pharmacology Specialty Uses of Chemicals Chemistry Chemical Actions and Uses Natural Science Disciplines Biological Science Disciplines Disciplines and Occupations Chemicals and Drugs Drug Design Small Molecule Libraries Combinatorial Chemistry Techniques Drug Discovery Methods Médicaments > Conception. Chimie pharmaceutique. Techniques pharmaceutiques. Pharmacologie. Chimie. Sciences physiques. Sciences de la vie. Méthodologie. pharmacology. chemistry. physical sciences. biological sciences. methodology. MEDICAL > Pharmacology. Physical sciences Pharmaceutical technology Pharmaceutical chemistry Methodology Life sciences Drugs > Design Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Overview : fragment based drug design
Designing and searching fragment libraries
Validation of reaction vectors for de novo design
Design and application of fragment libraries for protein crystallography
Ligand-based virtual screening using Bayesian inference network
A computational fragment approach by mining the protein data bank: library design and bioisosterism
Computational screening : docking
A fragment based docking engine : eHiTS
Fragment-based high-throughput docking and library tailoring
Leads from fragments : fragment growing and linking
Fragment-based high-throughput docking and library tailoring
Fragment-based drug discovery for diseases of the central nervous system.