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Approaching the next inflection in peptide therapeutics : attaining cell permeability and oral bioavailability /

"This book is about peptide therapeutics"--

Bibliographic Details
Corporate Author: American Chemical Society. Division of Medicinal Chemistry (sponsoring body.)
Other Authors: Ghodge, Swapnil V. (Editor), Biswas, Kaustav (Editor), Golosov, Andrei A. (Editor)
Format: eBook
Language:English
Published: Washington, DC : American Chemical Society, [2022]
Series:ACS symposium series ; 1417.
Subjects:
Peptide drugs > Bioavailability.
Peptides > Research.
Cells > Permeability.
Proteins > Conformation.
Peptides > therapeutic use
Peptides > metabolism
Drug Discovery
Cell Membrane Permeability
Protein Conformation
Cellules > Perméabilité.
Protéines > Conformation.
Médicaments peptidiques > Biodisponibilité.
Peptides > Recherche.
Cells > Permeability
Peptides > Research
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Peptide drug discovery raison d'etre : engineering mindset, design rules, and screening tools
  • mRNA display and its growing potential in the discovery of de novo therapeutic peptide candidates
  • Computational design of peptide-based binders to therapeutic targets
  • The roles of conformations on predictions of peptide properties
  • Matching simulations and experiments of conformationally flexible cyclic peptides : steps towards a holistic view of passive membrane permeability
  • NMR spectroscopy for studying peptide conformations and cell permeability
  • Designing cell-permeable peptide therapeutics that enter the cell by endocytosis
  • Design and discovery of orally bioavailable macrocycles : toward orally bioavailable peptide therapeutics
  • Formulation strategies to enable delivery of therapeutic peptides across cell membranes
  • Optimization of peptide drug exposures for pharmacological efficacy : DMPK considerations.