Chemical process research : the art of practical organic synthesis /
Annotation
| Other Authors: | , |
|---|---|
| Format: | eBook |
| Language: | English |
| Language Notes: | English. |
| Published: |
Washington, DC :
American Chemical Society,
©2004.
|
| Series: | ACS symposium series ;
870. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Machine derived contents note: Preface ix
- 1. Reflections on Process Research 1
- Edward J.J. Grabowski
- 2. Synthesis of Cell Adhesion Inhibitors via
- Crystallization-Driven Dynamic Transformations 23
- Magnus Eriksson, Vittorio Farina, Suresh Kapadia,
- Elio Napolitano, and Nathan K. Yee
- 3. Synthetic, Structural, and Mechanistic Issues in the Development of a Subtype Selective GABA
- Partial Agonist Hypnotic Agent 39
- John A. Ragan, Jerry A. Murry, Michael J. Castaldi,
- Alyson K. Conrad, Paul D. Hill, Brian P. Jones,
- Narasimhan Kasthurikrishnan, Bryan Li, Teresa W. Makowski,
- Ruth McDermott, Barb J. Sitter, Timothy D. White,
- and Gregory R. Young
- 4. Process Research and Initial Scale-Up of ABT-839:
- A Farnesyltransferase Inhibitor 59
- Todd S. McDermott, Ramiya Premchandron, Anne E. Bailey,
- Lakshmi Bhagavatula, and Howard E. Morton
- 5. Synthetic Approaches to the Retinoids 71
- Margaret M. Faul
- 6. Design of Experiments in Pharmaceutical Process Research and
- Development 87
- John E. Mills
- 7. Process Development for the MMP Inhibitor AG3433 111
- Jayaram K. Srirangam, Ming Guo, Shu Yu, Alan W. Grubbs,
- James Saenz, Steven L. Bender, Judith G. Deal, Kuenshan S. Lee,
- Jason Liou, Robert Szendroi, James Faust, and Kim Albizati
- 8. Dihydro-7-benzofurancarboxylic Acid: An Intermediate
- in the Synthesis of the Enterokinetic Agent R108512 125
- Bert Willemsens, Alex Copmans, Dirk Beerens, Stef Leurs,
- Dirk de Smaele, Max Rey, and Silke Farkas
- 9. Process Research Leading to an Enantioselective
- Synthesis of a 5-Lipoxygenase Inhibitor for Asthma 141
- David B. Damon, Michael Butters, Robert W. Dugger,
- Peter Dunn, Sally Gut, Brian P. Jones, Thomas G. LaCour,
- C. William Murtiashaw, Harry A. Watson Jr., James Weeks,
- and Timothy D. White
- 10. A Practical Synthesis of Tetrasubstituted
- Imidazole p38 MAP Kinase Inhibitors: A New Method
- for the Synthesis of a-Amidoketones 161
- Jerry A. Murry, Doug Frantz, Lisa Frey, Arash Soheili,
- Karen Marcantonio, Richard Tillyer, Edward J.J. Grabowski,
- and Paul J. Reider
- 11. Solution Phase Synthesis of the Pulmonary
- Surfactant KL4: A 21 Amino Acid Synthetic Protein 181
- Ahmed F. Abdel-Magid, Mary Ellen Bos, Urs Eggmann,
- Cynthia A. Maryanoff, Lorraine Scott, Adrian Thaler,
- and Frank J. Villani
- Indexes
- Author Index 201
- Subject Index 203.