Table of Contents:
  • Cancer drug discovery and development : new paradigms for a new millennium / E.A. Sausville [and others]
  • Evolutionary biosynthesis of anticancer drugs / George R. Pettit
  • Some recent developments in the synthesis and structure-activity relationship of novel taxanes / John F. Kadow [and others]
  • New generation taxoids and hybrids of microtubule-stabilizing anticancer agents / Iwao Ojima [and others]
  • Discodermolide and taxol : a synergistic drug combination in human carcinoma cell lines / Susan Band Horwitz [and others]
  • Highly efficient semisynthesis of biologically active epothilone derivatives / Gregory D. Vite [and others]
  • Synthetic and semisynthetic analogs of epothilones : chemistry and biological activity / Karl-Heinz Altmann [and others]
  • Synthesis and biological activity of epothilones / Ulrich Klar [and others]
  • Epothilones and sarcodictyins : from combinatorial libraries to designed analogs / Nicolas Winssinger and K.C. Nicolaou
  • Synthesis and structure-activity relationship studies of cryptophycins : a novel class of potent antimitotic antitumor depsipeptides / Chuan Shih [and others]
  • Farnesyltransferase inhibitors as potential anticancer agents / J.B. Gibbs [and others]
  • Farnesyltransferase inhibitors : from squalene synthase inhibitors to the clinical agent BMS-214662 / John T. Hunt
  • Inhibiting farnesyl protein transferase with Sch-66336 : potentially a selective noncytotoxic therapy for human cancer / A.G. Taveras [and others]
  • Pyrrolo[2,3-d]pyrimidine and pyrazolo[3,4-d]pyrimidine derivatives as selective inhibitors of the EGF receptor tryosine kinase / G. Caravatti [and others]
  • STI571 : a new treatment modality for CML? / Jürg Zimmermann, Pascal Furet, and Elisabeth Buchdunger
  • The discovery and development of second-generation matrix metalloproteinase inhibitors for the treatment of cancer / Andy Baxter and John Montana
  • Prospects for antiangiogenic therapies based upon VEGF inhibition / Pascal Furet and Paul W. Manley
  • Carbohydrate-based tumor antigens as antitumor vaccine agents / Jennifer R. Allen and Samuel J. Danishefsky
  • Drugs to enhance the therapeutic potency of anticancer antibodies : antibody-drug conjugates as tumor-activated prodrugs / Walter A. Blättler and Ravi V.J. Chari.