rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: From planning to implementation
    sub title: the challenges of recruiting older adults with Parkinson's to a feasibility trial
  name:
    name part: Edelstyn, Nicola M. J.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Sim, Julius
    role:
      role term: author.
  name:
    name part: Lancaster, Gillian M. J.
    role:
      role term: editor.
  type of resource: text
  genre: bibliography
  genre: Case studies
  origin info:
    place:
      place term: enk
    date issued: 2020
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource : illustrations.
  abstract: MeMory PaD was a 24-month feasibility trial of two slow-release dopamine agonists, pramipexole, and ropinirole, prescribed in Parkinson's to manage movement problems. MeMory PaD opened in April 2013 and closed in September 2015. A total of 220 patients were pre-screened for eligibility, and 145 were excluded because they were not already on either pramipexole or ropinirole, their dopamine agonist dose was too high, they had a co-morbid neurological condition, or they were over 80 years of age. Seventy-five patients were invited to participate. Enrollment was low, with 53 people with Parkinson's declining our invitation. This is unsurprising, since we were asking patients to change their Parkinson's medication and to undergo periods of medication withdrawal. Nevertheless, 22 people with Parkinson's agreed to take part, and 14 completed the study. The low recruitment rate reflects, in part, concerns about switching dopamine agonists and the risk this has for experiencing side-effects and a worsening of Parkinson's, too many appointments and difficulty getting to the research centers because of mobility problems, the research process and not knowing the researchers, and increasing the workload for carers or family members. Nine participants experienced adverse events and were either withdrawn or were swapped back to their original dopamine agonist, but stayed in the study. This allowed us to test the clinical support for participants with adverse events present. Different methods of recruiting participants have also been explored. These include raising awareness with promotional material in local newspapers and pharmacies, and forming links with other recruitment sites such as general practitioner surgeries.
  target audience: specialized
  note: Nicola M. J. Edelstyn, Julius Sim ; edited by Gillian A. Lancaster.
  note: Includes bibliographical references and index.
  subject:
    topic: Drugs
    topic: Testing
    genre: Case studies
  subject:
    topic: Clinical trials
    genre: Case studies
  subject:
    topic: Parkinson's disease
    topic: Patients
    genre: Case studies
  subject:
    topic: Médicaments
    topic: Essais cliniques
    genre: Études de cas
  subject:
    topic: Études cliniques
    genre: Études de cas
  subject:
    topic: Parkinsoniens
    genre: Études de cas
  subject:
    topic: Clinical trials
  subject:
    topic: Drugs
    topic: Testing
  subject:
    topic: Parkinson's disease
    topic: Patients
  classification: RM301.27 .E34 2020
  classification: 615.1901
  related item:
    title info:
      title: SAGE Research Methods Cases : Medicine and Health
  identifier: 9781529742503
  identifier: 1529742501
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: SGPBL
    record creation date: 200616
    record change date: 20240923170309.6
    record identifier: in00005494310
    language of cataloging:
      language term: eng