rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Novel Antimicrobials and Drug Delivery Devices to Treat Multidrug Resistant Infections
  name:
    name part: Chirra, Bhagath
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Cannon, Carolyn
    role:
      role term: thesis advisor.
  name:
    name part: Texas A&M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2023
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: The discovery and development of antibiotics in the early 20th century led to a significant reduction in mortality from infectious diseases. However, the age of antibiotics has coincided with the accelerated emergence of antimicrobial resistance (AMR). Bacteria, armed with diverse resistance mechanisms, began developing resistance to antibiotics immediately after their deployment and sometimes even during the development process. In fact, the AMR crisis has reached a critical point, where bacteria have become multidrug resistant (MDR) rendering even the last-resort antibiotics in our arsenal impotent. Specifically, bacterial infections from ESKAPE pathogens have become paradigms of infection and resistance. The research presented in this study utilized three strategies that have the potential to address the AMR crisis and improve human health: 1) identification of novel compounds from different ecological niches, 2) repurposing and combining drugs, and 3) use of nanosized drug delivery systems. Particularly, pulmonary and chronic wound infections from P. aeruginosa and S. aureus will be studied to evaluate the strategies used to address the AMR crisis. First, a known antibiotic, ciprofloxacin, was encapsulated within liposomes functionalized with targeting moieties to deliver the drug directly to the site of infection. Utilizing a murine infection model, a significant survival advantage was observed in mice treated with targeted ciprofloxacin-liposomes compared to nontargeted ciprofloxacin liposomes. Then, we assessed novel compounds for antimicrobial efficacy, alone and in combination, against R. equi, an equine pathogen that causes pneumonia in foals. Specifically, a combination treatment of a novel antimicrobials, gallium maltolate (GaM) and C58, isolated from marine bacterium, has demonstrated antimicrobial efficacy against intracellular R. equi. Similarly, C58 loaded nanoparticles, along with GaM treatment also significantly reduced the bacterial burden of intr…
  note: by Bhagath Chirra.
  note: "Major Subject: Medical Sciences"
  note: Includes vita.
  note: Doctor of Philosophy Texas A&M University 2022 https://hdl.handle.net/1969.1/197929
  note: Includes bibliographical references.
  note: Text (Dissertation)
  subject:
    topic: Major Medical Sciences
  subject:
    topic: Antimicrobial Resistance
  subject:
    topic: Novel Antimicrobials
  subject:
    topic: Nanosized drug delivery devices
  subject:
    topic: nanoparticles
  subject:
    topic: liposomes
  subject:
    topic: electrospinning
  identifier: https://hdl.handle.net/1969.1/197929
  record info:
    record content source: TXA
    record creation date: 240826
    record change date: 20240829173512.8
    record identifier: in00005468538
    language of cataloging:
      language term: eng