rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Understanding the Mechanisms of Gestational Exposure to Ultrafine Particulate Matter on Placental Development and Dysfunction in a Murine Model
  name:
    name part: Behlen, Jonathan Charles
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Johnson, Natalie
    role:
      role term: thesis advisor.
  name:
    name part: Texas A&M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2023
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: Particulate matter (PM) air pollution is of growing concern due to increasing evidence of its ability to cause adverse health effects, particularly during development. PM represents a heterogenous mixture of compounds divided into three categories based upon their size (i.e., aerodynamic diameter): coarse (2.5-10 ℗æm), fine (<2.5 ℗æm), and ultrafine (<0.1 ℗æm). Currently, there is no established regulatory limit or guideline for ultrafine particulate (UFP) exposure. Recent data supports the ability of UFPs to impact the placenta directly, via particle translocation, and indirectly, through oxidative stress-related mechanisms. It is well documented that any disruption within the placenta will affect its ability to function, thus potentially negatively impacting crucial windows of fetal growth and development. Given the gap in knowledge concerning the mechanisms of action regarding UFP exposure during pregnancy on placental development, we conducted several in vivo studies in a mouse model to investigate the impact of gestational UFP exposure on signaling pathways in placental development. We sought to clarify the role of Nrf2, the master regulator of antioxidant signaling as it relates to UFP exposure. Our findings yield a greater molecular understanding of UFP-driven placental dysfunction. These outcomes confirm how UFP exposure impacts placental development and highlight the importance of the antioxidant response pathway. Ultimately, this research adds to the body of literature that can inform preventive strategies to mitigate maternal exposure and protect fetal health. The electronic version of this dissertation is accessible from https://hdl.handle.net/1969.1/197254
  note: by Jonathan Behlen.
  note: "Major Subject: Toxicology"
  note: Includes vita.
  note: Doctor of Philosophy Texas A&M University 2022 https://hdl.handle.net/1969.1/197254
  note: Includes bibliographical references.
  note: Text (Dissertation)
  subject:
    topic: Major Toxicology
  subject:
    topic: Developmental and Reproductive Toxicology
  subject:
    topic: Ultrafine Particulate Matter
  subject:
    topic: Placenta
  identifier: https://hdl.handle.net/1969.1/197254
  record info:
    record content source: TXA
    record creation date: 240819
    record change date: 20240820145859.5
    record identifier: in00005463630
    language of cataloging:
      language term: eng