rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Function and evolution of repeated DNA sequences
  name:
    name part: Richard, Guy-Franck
    role:
      role term: editor.
  type of resource: text
  origin info:
    place:
      place term: enk
    date issued: 2023
    copyright date: 2023
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (400 pages).
  abstract: The genome of a living being is composed of DNA sequences with diverse origins. Beyond single-copy genes, whose product has a biological function that can be inferred by experimentation, certain DNA sequences, present in a large number of copies, escape the most refined approaches aimed at elucidating their precise role. The existence of what 20th century geneticists had already perceived (and wrongly described as "junk DNA"!) was confirmed by the sequencing of the first complex genomes, including that of Homo sapiens. A large part of what defines a living thing is not unique, but repeated, sometimes a very large number of times, increasing in complexity with successive duplications and multiplication. Understanding and defining the many functions of this myriad of repeated sequences, as well as their evolution through natural selection, has become one of the major challenges for 21st century genomics.
  table of contents: Foreword xiii Bernard DUJON -- Introduction xv Guy-Franck RICHARD -- Chapter 1 Whole-Genome Duplications, a Source of Redundancy at the Entire-Genome Scale 1 Elise PAREY and Camille BERTHELOT -- 1.1 Prevalence of polyploids in the tree of life -- 1.1.1 Whole duplications in eukaryotes -- 1.1.2 Polyploidies in prokaryotic organisms -- 1.1.3 Polyploid cells in normal and pathological physiology -- 1.2 Mechanisms for the appearance of whole-genome duplications -- 1.2.1 Non-separation of chromosomes after replication -- 1.2.2 Autopolyploidization, a perfect genome redundancy -- 1.2.3 Allopolyploidization, an overlapping of genomes of similar species -- 1.3 Cellular consequences of whole-genome duplications -- 1.3.1 Disruption of cell and nucleus organization -- 1.3.2 Modifications in the expression of genes and transposons -- 1.3.3 Unstable meiosis -- 1.4 Rediploidization: evolutionary reduction in genetic redundancy -- 1.4.1 Resolution of meiosis by karyotype rearrangement -- 1.4.2 Evolutionary divergence of duplicated sequences -- 1.4.3 Bias and dominance during rediploidization -- 1.4.4 Incomplete and lineage-specific rediploidizations -- 1.5 Functions and evolution of duplicated genes -- 1.5.1 Redundancy and subfunctionalization -- 1.5.2 Neofunctionalization and evolutionary innovations -- 1.5.3 Gene repertoire bias -- 1.5.4 Regulatory blocks and splitting of regulatory regions -- 1.6 Whole-genome duplications and evolutionary diversification -- 1.6.1 Association with geological crises -- 1.6.2 Evolutionary speciations and radiations -- 1.7 Perspectives and conclusions -- 1.8 References -- Chapter 2 Segmental Duplications and CNVs: Adaptive Potential of Structural Polymorphism 47 Patricia BALARESQUE and Franklin DELEHELLE -- 2.1 The multiple facets of genetic polymorphism -- 2.2 From Segmental Duplications to Copy Number Variants: terminology -- 2.3 SDs: a general overview -- 2.3.1 Background -- 2.3.2 SDs: more than a category of sequences, superstructures -- 2.3.3 …
  table of contents: Triplet repeat expansion disorders -- 7.4.2 Colorectal cancers and the mismatch repair system -- 7.4.3 Fragile sites -- 7.5 De novo fo.
  table of contents: rmation and evolution of tandem repeats -- 7.5.1 Birth and death of microsatellites -- 7.5.2 Formation of minisatellites -- 7.6 Perspectives -- 7.6.1 Inadequacy of software tools -- 7.6.2 The importance of definitions in biology -- 7.7 Acknowledgments -- 7.8 References -- Chapter 8 CRISPR-Cas: An Adaptive Immune System 319 Marie TOUCHON -- 8.1 A brief history of the discovery of CRISPR-Cas systems -- 8.2 General characteristics of CRISPR-Cas systems -- 8.2.1 Diversity of repeats -- 8.2.2 Diversity and origin of spacers -- 8.2.3 Diversity and evolutionary classification of cas genes -- 8.2.4 Origin of CRISPR-Cas systems -- 8.3 Evolution of CRISPR-Cas systems -- 8.3.1 Scattered distribution of CRISPR-Cas systems -- 8.3.2 Massive transfer of CRISPR-Cas systems -- 8.3.3 Commonly lost systems -- 8.3.4 Evolutionary dynamics of CRISPR arrays -- 8.4 An adaptive immune system -- 8.4.1 A three-stage immune response -- 8.4.2 Diversity of CRISPR-Cas molecular mechanisms -- 8.4.3 Self- and none self-discrimination: avoiding self-targeting by CRISPR -- 8.5 Phage escape mechanisms -- 8.5.1 Genomic modifications -- 8.5.2 Anti-CRISPR proteins -- 8.6 Biological cost of CRISPR-Cas systems -- 8.6.1 Cost of expression -- 8.6.2 Cost of autoimmunity -- 8.6.3 The genetic background of the host -- 8.6.4 Limiting horizontal gene transfer -- 8.6.5 Naive and primed adaptation -- 8.7 Importance in nature: impact of ecological factors -- 8.7.1 Phage diversity - mutation rate -- 8.7.2 Phage diversity - population size -- 8.7.3 Infectious risk - alternative strategies -- 8.8 Conclusions and perspectives -- 8.9 References -- List of Authors -- Index.
  note: coordinated by Guy-Franck Richard.
  subject:
    topic: Nucleotide sequence
  classification: QP625.N89 F86 2023
  classification: 572.8/633
  related item:
    title info:
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  identifier: 9781394264902
  identifier: 1394264909
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  identifier: 1394264887
  identifier: 9781789451191
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: NhCcYBP
    record creation date: 240118
    record change date: 20260214210800.5
    record identifier: in00004786587
    language of cataloging:
      language term: eng