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Quantification, validation and uncertainty in analytical sciences : an analyst's companion /

Quantification, Validation and Uncertainty in Analytical Sciences Companion guide explaining all processes in measuring uncertainty in quantitative analytical results Quantification, Validation and Uncertainty in Analytical Sciences provides basic and expert knowledge by building on the sequence of...

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Bibliographic Details
Main Authors: Feinberg, Max (Author), Rudaz, Serge (Author)
Format: eBook
Language:English
Published: Weinheim : Wiley-VCH, 2024.
Subjects:
Quantitative research.
Analytical chemistry > Quantitative.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • List of Figures
  • List of Resources
  • Preface
  • Glossary of Symbols
  • Acknowledgments
  • 1 Quantification
  • 1.1 Define the Measurand (Analyte)
  • 1.2 Calibration Modes
  • 1.3 External Calibration (EC)
  • 1.4 In-sample Calibration (ISC)
  • 1.5 Some New Quantification Techniques
  • 2 Calibration
  • 2.1 Direct and Inverse Calibration
  • 2.2 Least-squares Regression Method
  • 2.3 Software Implementation
  • 2.4 Calibration: Special Topics
  • 2.5 Metrological Approach to Calibration
  • 3 Precision
  • 3.1 Outputs of Interlaboratory Studies
  • 3.2 Analysis of Variance (ANOVA)
  • 3.3 Balanced and Unbalanced Experimental Design
  • 3.4 Software Implementation
  • 4 Trueness
  • 4.1 Trueness and True Value
  • 4.2 Assessment of Trueness
  • 4.3 Proficiency Testing
  • 4.4 Control Charts
  • 5 Method Validation
  • 5.1 Review of Validation Procedures
  • 5.2 Method Accuracy Profile (MAP)
  • 5.3 Statistical Dispersion Intervals
  • 5.4 Accuracy Profile: Special Topics
  • 6 Measurement Uncertainty (MU)
  • 6.1 Principle of Measurement Uncertainty
  • 6.2 General Procedure to Estimating MU
  • 6.3 Traceability at the International System of Units
  • 6.4 Stage 1. Specify the Measurand
  • 6.5 Stage 2. Identify Uncertainty Components
  • 6.6 Stage 3. Quantify Uncertainty Sources
  • 6.7 Stage 4. Calculate Combined Uncertainty
  • 6.8 Calculate Expanded Uncertainty
  • 6.9 Round the Result
  • 6.10 Accuracy, Total Error, and Uncertainty
  • 6.11 Insights on Probability
  • 7 Measurement Uncertainty in Analytical Sciences
  • 7.1 Published Procedures: An Evaluation
  • 7.2 Use Method Accuracy Profile Data
  • 7.3 Use Control Charts Data
  • 7.4 Use Interlaboratory Comparison Data
  • 7.5 Uncertainty Functions
  • 7.6 Concept of Coverage Interval
  • 8 Measurement Uncertainty and Decision
  • 8.1 Framework for Decision-Making
  • 8.2 Sample Conformity Assessment
  • 8.3 Sampling Uncertainty
  • 8.4 Measurement Uncertainty: Special Issues
  • 9 MU and Quantification Limits
  • 9.1 Definitions and Assessment of LOQ
  • 9.2 LOQ as an Expected Relative Uncertainty
  • 9.3 Decision Limit and Detection Capability
  • 10 Examples of MU Application
  • 10.1 Standard Addition Method and Drug Quality
  • 10.2 Method Comparison Using Uncertainty
  • 11 Conclusions
  • 11.1 Role of the Number of Replicates
  • 11.2 Traceability to International Units
  • 11.3 Education about Uncertainty
  • 11.4 Risk Analysis
  • 11.5 Harmonization of MU Estimation Procedures
  • Annexes
  • The 10-step MAP Procedure
  • Glossary of Used Terms
  • Acronyms
  • Reference
  • Index.