| Abstract: | Rats and fish were used to study the effect of diets differing only in carbohydrate supplement on the specific activity of the enzyme acetyl coenzyme A carboxylase which catalyzes the first step in the de novo biosynthesis of lipids. The carbohydrates fed were glucose, fructose or glycerol. Glucose is metabolized in an insulin-regulated pathway while the other two sugars are not in mammals. It was found that normal rats have about the same acetyl coenzyme A carboxylase activity regardless of diet when fed for a seven day period. The marine catfish, Arius felis apparently cannot tolerate a diet containing 17.7% fructose. |
|---|