Description
| Abstract: | The specific aim of this study was to determine the capacity of the maternal rat liver to bioactivate aflatoxin B₁ on day 6 of gestation. Lowry protein determinations on rat liver microsome preparations revealed on increase in the total amount of microsomal protein per gram of liver tissue in pregnant Sprague-Dawley rats on day 6 of gestation as compared to nonpregnant control animals. In vitro, microsomes from day 6 pregnant animals showed an enhanced capability to bioactivate aflatoxin B₁ resulting in a two-fold increase in the level of binding of aflatoxin B₁ to DNA when compared to nonpregnant controls. It was thus concluded that these is gestation-specific activation of aflatoxin B₁ in pregnant Sprague-Dawley rats with greater hepatic aflatoxin B₁ activation present on day 6 of gestation as compared to nonpregnant control rats. This increased hepatic bioactivation indicates the enhanced production of microsomal enzymes capable of activating aflatoxin B₁. |
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| Item Description: | Undergraduate thesis written for Program year: 1983-1984 |
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| Physical Description: | 1 online resource (57 pages).
Digitized from print version held at Pickle Center High Density Storage, HDR barcode A14850697856 |
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