| Tag |
First Indicator |
Second Indicator |
Subfields |
| LEADER |
00000nmm a2200000Ia 4500 |
| 001 |
in00004781913 |
| 008 |
231116s1983 txu f u # eng d |
| 005 |
20240311193104.8 |
| 099 |
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|a BeckD 1983
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| 100 |
1 |
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|a Beck, DeAndra.
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| 245 |
1 |
0 |
|a Genetic Manipulation of Aspartate Transcarbamylases from Escherichia coli and Serratia Marcescens.
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| 264 |
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1 |
|a [College Station, Texas] :
|b Texas A&M University,
|c 1983.
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| 300 |
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|a 1 online resource (32 pages).
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 500 |
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|a Undergraduate thesis written for Program year: 1982-1983
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| 502 |
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|a University Undergraduate Fellows, sponsored by Biochemistry Department.
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| 520 |
3 |
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|a Aspartate transcarbamylase (ATCase, EC 2.1.3.2) allosterically modulates de novo pyrimidine biosynthesis in the enteric bacteria. This modulation differs in Escherichia coli and Serratia marcescens, with CTP allosterically inhibiting ATCase from E. coli and activating the enzyme in S. marcescens. The enzyme is composed of two catalytic trimers and three regulatory dimmers encoded by the pyrB and pyrI genes respectively. These adjacent cistrons are organized into a single control region to achieve coordinated biosynthesis of the catalytic and regulatory polypeptide chains necessary to form the holoenzyme. The genes for ATCase from the two organisms may be manipulated by in vitro recombinant DNA techniques. After the structure of the pyrBI genes encoding ATCase are characterized, they may be genetically altered and then transformed back into appropriate strains. The in vivo effects may then be studied. Eventually, DNA sequencing may be done for evaluation of evolutionary trends.
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| 530 |
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|a Digitized from print version held at Pickle Center High Density Storage, HDR barcode A14851268053
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| 535 |
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|a HDR
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| 653 |
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|a ATCase
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| 653 |
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|a bacteria strains
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| 653 |
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|a gene encoding
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| 653 |
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|a genetic alteration
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| 653 |
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|a pyrB genes
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| 653 |
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|a pyrI genes
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| 655 |
|
7 |
|a Undergraduate thesis
|2 local
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| 700 |
1 |
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|a Wild, James R.,
|e degree supervisor.
|
| 856 |
4 |
0 |
|z Available on OAKTrust.
|u https://oaktrust.library.tamu.edu/handle/1969.1/CAPSTONE-BeckD_1983
|t 0
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| 887 |
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|a A14851268053
|
| 999 |
f |
f |
|s a8188db4-c9db-466f-854d-dd050f8f3ced
|i 2d82c492-cc61-421c-b611-9d4012dd2be7
|t 0
|
| 952 |
f |
f |
|a Texas A&M University
|b College Station
|c Electronic Resources
|d Available Online
|t 0
|e BeckD 1983
|f Capstone
|g Electronic
|h Other scheme
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| 998 |
f |
f |
|a BeckD 1983
|t 0
|l Available Online
|