rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Induction of Esterases in Various Mouse Tissues by Carcinogens
  name:
    name part: Massey, Teresa Louise.
    role:
      role term: creator
  name:
    name part: Womack, James E.
    role:
      role term: degree supervisor.
  type of resource: software, multimedia
  genre: Undergraduate thesis
  origin info:
    place:
      place term: txu
    date issued: 1982
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    extent: 1 online resource (24 pages).
  abstract: A number of known chemical carcinogens were tested as potential inducers of mouse tissue esterases. Only the nitrosamines, DEN and DPN, altered the electrophoretic profiles of esterases in this study. While nitrosamines had been previously shown to increase esterase levels in mouse plasma, the tissue source and specific genes involved in this increase were not demonstrated. This study indicated that the increased plasma esterase levels were due primarily to increased enzyme production in the liver. More specifically, the product of the ES-11 gene on chromesome 8 was a major contributor to the elevated levels. Closely linked ES-2 and ES-6 genes were not induced by these stimuli. A subcellular study revealed that the increased levels of ES-11 accumulated primarily in the microsomal fraction, probably due to an increased rate of protein synthesis. The time limitations of this study and the difficulty of isolating the product of the ES-11 gene did not allow final verification of this hypothesis.
  target audience: specialized
  note: Undergraduate thesis written for Program year: 1981/1982
  note: Digitized from print version held at Pickle Center High Density Storage, barcode 24829681
  note: University Undergraduate Fellows, sponsored by Biomedical Sciences Department.
  note: HDR
  subject:
    topic: chemical carcinogen
  subject:
    topic: enzyme production
  subject:
    topic: microsomal fraction
  subject:
    topic: mouse esterase
  subject:
    topic: nitrosamines
  subject:
    topic: protein synthesis
  identifier: https://oaktrust.library.tamu.edu/handle/1969.1/CAPSTONE-MasseyT_1982
  record info:
    record creation date: 231116
    record change date: 20240301201633.0
    record identifier: in00004780708