rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Effects Of Cortisol On The Development Of The Chick Brain
  name:
    name part: Krum, Ted.
    role:
      role term: creator
  name:
    name part: Bhaskaran, Govindan
    role:
      role term: degree supervisor.
  type of resource: software, multimedia
  genre: Undergraduate thesis
  origin info:
    place:
      place term: txu
    date issued: 1982
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    extent: 1 online resource (10 pages).
  abstract: Many hormones appear to affect the development of the embryonic central nervous system (CNS), causing either gross morphological defects or subtle changes in the functional maturation of neurons which are manifested as post-natal behavioral aberrations. To cite examples, certain glucocorticoids, especially cortisol, have been shown to induce morphological defects such as in myelination development and brain maturation, and biochemical changes such as altering enzyme levels in the brain, oxygen consumption of the brain, and amino acid metabolism during development of the CNS. The primary role of these hormones in developing neurons is, however, not understood. Evidence also suggests that experimental alterations of neurotransmitter synthesis may lead to degeneration of both postsynaptic and presynaptic neurons, and may inhibit functional maturation of neurons. The interactions between hormones and neurotransmitter synthesis in the embryonic brain remains to be elucidated. But, recent findings indicate that hormones may directly or indirectly influence neurotransmitter synthesis. For example, hypothyroidism in embryos leads to reduced synaptogenesis and transmitter synthesis, and thyroxin treatment restores normal development. It has also been discovered that application of thyroid hormones greatly increases the branching of neuronal processes. The intracellular effects of many hormones are mediated either directly or indirectly by the cyclic adenosine monophosphate (cAMP) as a second messenger. The central role of cAMP and the cAMP dependent protein kinases (A-PK) in neurotransmitter synthesis and/or transduction of neurotransmitter action suggests that some of the hormonal effects may be controlled via the cAMP - A-PK system. cAMP itself binds to specific receptor proteins which are generally subunits of a class of enzymes, the cyclic adenosine monophosphate dependent protein kinases (A-PK) which catalyze the phosphorolation, via adenosine triphosphate (ATP), of var…
  target audience: specialized
  note: Undergraduate thesis written for Program year: 1981/1982
  note: Digitized from print version held at Pickle Center High Density Storage, barcode 24829681
  note: University Undergraduate Fellows, sponsored by Biochemistry Department.
  note: HDR
  subject:
    topic: adenosine monophosphate dependent protein kinases
  subject:
    topic: central nervous system
  subject:
    topic: chick embryos
  subject:
    topic: cyclic adenosine monophosphate
  subject:
    topic: glucocorticoids
  subject:
    topic: hormones
  identifier: https://oaktrust.library.tamu.edu/handle/1969.1/CAPSTONE-KrumT_1982
  record info:
    record creation date: 231116
    record change date: 20240301201632.8
    record identifier: in00004780690