Polymers and nanomaterials for gene therapy /
Polymers and Nanomaterials for Gene Therapy explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and na...
| Other Authors: | |
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| Format: | eBook |
| Language: | English |
| Published: |
Amsterdam :
Elsevier/Woodhead Publishing,
[2016]
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| Series: | Woodhead Publishing series in biomedicine ;
no. 83. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book. |
| Summary: | Polymers and Nanomaterials for Gene Therapy explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. |
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| Physical Description: | 1 online resource : illustrations |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 9780081005217 0081005210 |