Bioprocess and Analytics Development for Virus-based Advanced Therapeutics and Medicinal Products (ATMPs) /

This book reviews the knowledge, methods and available techniques in the rapidly advancing field of virus based vaccines and gene therapeutics. It also highlights new innovative tools and interdisciplinary techniques for bioprocess development and analytics of viruses and viral vectors. As such, it...

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Bibliographic Details
Corporate Author:	SpringerLink (Online service)
Other Authors:	Gautam, Saurabh (Editor), Chiramel, Abhilash I. (Editor), Pach, Roland (Editor)
Format:	eBook
Language:	English
Published:	Cham : Springer International Publishing : Imprint: Springer, 2023.
Edition:	1st ed. 2023.
Subjects:	Virology. Biomedical engineering. Biotechnology. Microbial genetics. Analytical biochemistry. Therapeutics. Biomedical Engineering and Bioengineering. Microbial Genetics. Analytical Biochemistry. Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Chapter 1: Bioprocessing and analytical development for virus-based therapeutics
Chapter 2: Viral Vector Upstream Processing and Clarification
Chapter 3: Upstream processing of viral therapeutics: From host cell expansion to virus production
Chapter 4: Leveraging virus biology and host genetic conflicts for cell line development and engineering for virus-based therapeutics
Chapter 5: Overview of Current Downstream Processing for Modern Viral Vectors
Chapter 6: Filtration Principles and Techniques for Bioprocessing of Viral Vector-Based Therapeutics
Chapter 7: Chromatographic purification of viruses: State of the art and current trends
Chapter 8: Purifying Viral Vectors - A Review of Chromatography Solutions
Chapter 9: Particle analytics - Comparative approaches for analysis of viral vectors
Chapter 10: Phase-Appropriate Potency Assay Development for AAV-based Gene Therapy Products
Chapter 11: Quantification of virus infectivity - the key assay for the development of viral therapeutics
Chapter 12: Product-related impurities in therapeutic virus bioprocessing
Chapter 13: Process Analytical Technologies (PAT) and Quality by Design (QbD) for bioprocessing of virus-based therapeutics
Chapter 14: Methods and practical considerations in imaging viral therapeutics
Chapter 15: Application of NMR Spectroscopy in Viral Assembly Characterization
Chapter 16: Improved Production Strategies for Oncolytic Measles Viruses as a Therapeutic Cancer Treatment
Chapter 17: Recent Advancements and Challenges in Recombinant Expression for Commercial Production of Virus Like Particles (VLPs)
Chapter 18: Oncolytic viruses and viral gene therapy vectors: Principles of safety.