Drug and therapy development for triple negative breast cancer /

Bibliographic Details
Other Authors: Kendrekar, Pravin (Editor), Adimule, Vinayak (Editor), Hurst, Tara (Editor)
Format: eBook
Language:English
Published: Weinheim, Germany : Wiley-VCH, [2023]
Subjects:
Online Access:Connect to the full text of this electronic book

MARC

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245 0 0 |a Drug and therapy development for triple negative breast cancer /  |c edited by Pravin Kendrekar, Vinayak Adimule, Tara Hurst. 
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505 0 |a Intro -- Title Page -- Contents -- Preface -- Part I History of Breast Cancer -- 1 Early-Stage Diagnosis of Breast Cancer: Amelioration in Approaches -- 1.1 Introduction -- 1.2 Imaging Techniques -- 1.2.1 Mammography (MG) -- 1.2.2 Ultrasonography (US) -- 1.2.3 Magnetic Resonance Imaging (MRI) -- 1.3 Microwave Breast Imaging Methods -- 1.3.1 Microwave Tomography -- 1.3.2 Radio-Based Microwave Imaging -- 1.4 Biomarkers and Biosensors for Breast Cancer Detection -- 1.4.1 Biomarkers -- 1.4.2 Biosensors -- 1.5 Conclusion -- Acknowledgment -- Conflict of Interest -- Authors Contribution 
504 |a References -- 2 DNA Replication Stress and Genome Instability in Breast Cancer -- 2.1 Introduction -- 2.2 Causes of Replication Stress and Genomic Instability -- 2.2.1 Replication Dysfunction -- 2.2.2 Transcription-Induced Stress -- 2.2.3 Genomic Aberrations and Instability -- 2.3 Molecular Mechanism of Genomic Instability -- 2.3.1 Problems Faced During DNA Damage Repair -- 2.3.2 Transcriptional Stress -- 2.3.3 CIN: Result of Defective Mitosis -- 2.4 Aftermath of Replication Stress on Cell and Its Fate -- 2.4.1 Conservation of Stalled Replication Forks 
505 8 |a 2.4.2 Chromosome Segregation Defect Check by HR Repair -- 2.4.3 Aging, Cell Death, and Senescence -- 2.5 Therapeutic Approach -- 2.6 Conclusion -- Abbreviations -- References -- 3 Recent Advancement of Nanotherapeutics to Treat Breast Cancer -- 3.1 Introduction -- 3.2 Pathophysiology of Breast Cancer -- 3.3 Classification of Breast Cancer -- 3.4 Techniques for Breast Cancer Detection -- 3.5 Current Breast Cancer Therapies -- 3.6 Nanotherapeutics for Breast Cancer Treatment and Metastasis -- 3.6.1 Nanodiamonds (NDs) -- 3.6.2 Intrinsic Toxicity Reduction -- 3.6.3 Diminishing Chemoresistance (CR) 
505 8 |a 3.6.4 Delivery of Combination Therapeutics Through NDs -- 3.7 Polymer-Based Nanoparticles (PBNPs) -- 3.8 Inorganic Nanoparticles (IONPs) -- 3.9 Hydrogels (HGLs) and Microbubbles (MBs) -- 3.10 Recent Patents of Nanotherapeutics for Breast Cancer Treatment -- 3.11 Clinical Trials of Nanotherapeutics for Breast Cancer -- 3.12 Conclusion and Future Perspectives -- References -- 4 HER Receptor in Breast Cancer -- 4.1 Introduction -- 4.2 Role of HER Receptors in the Human Body -- 4.3 HER2 Receptor in Breast Cancer Progression -- 4.4 Conclusion -- Conflict of Interest -- References 
505 8 |a 5 Human Endogenous Retroviruses in Triple-Negative Breast Cancer -- 5.1 Introduction -- 5.2 HERVs in Breast Cancer and TNBC -- 5.3 TROJAN lncRNA and TNBC -- 5.4 HERVs and Breast Cancer Treatments -- 5.5 Conclusion -- 5.6 Search Strategy -- References -- Part II Novel Drug Discovery and Development -- 6 Development in Drug Repurposing for the Treatment of Acute Leukemia Complicating Metastatic Breast Cancer -- 6.1 Introduction -- 6.1.1 Acute Leukemia's -- 6.1.2 Mitochondrial cAMP-PKA Signaling -- 6.1.3 Nuclear Compartment -- 6.1.4 Cytosolic Compartment and Plasma Membrane -- 6.2 Conclusion 
500 |a Conflict of Interest 
588 |a Description based on online resource; title from digital title page (viewed on June 28, 2023). 
650 0 |a Breast  |x Cancer  |x Treatment. 
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700 1 |a Kendrekar, Pravin,  |e editor. 
700 1 |a Adimule, Vinayak,  |e editor. 
700 1 |a Hurst, Tara,  |e editor. 
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