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Protein-ligand interactions from molecular recognition to drug design /

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The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specifici...

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Bibliographic Details
Other Authors: Böhm, Hans-Joachim, Schneider, Gisbert, 1965-
Format: eBook
Language:English
Language Notes:English.
Published: Weinheim : Wiley-VCH, ©2003.
Series:Methods and principles in medicinal chemistry ; v. 19.
Subjects:
Proteins.
Ligands.
Ligand binding (Biochemistry)
Carrier proteins.
Drugs > Design.
Ligands (Biochemistry)
Ligands
Carrier Proteins
Drug Design
Models, Molecular
Proteins
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Protein-Ligand Interactions From Molecular Recognition to Drug Design; Contents; Preface; A Personal Foreword; List of Contributors; List of Abbreviations; Prologue; 1 Prediction of Non-bonded Interactions in Drug Design; 2 Introduction to Molecular Recognition Models; 3 Experimental Approaches to Determine the Thermodynamics of Protein-Ligand Interactions; 4 The Biophore Concept; 5 Receptor-Ligand Interaction; 6 Hydrogen Bonds in Protein-Ligand Complexes; 7 Principles of Enzyme-Inhibitor Design; 8 Tailoring Protein Scaffolds for Ligand Recognition.