Drug bioavailability : estimation of solubility, permeability, absorption and bioavailability /
The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane perm...
| Other Authors: | , , |
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| Format: | eBook |
| Language: | English |
| Published: |
Weinheim :
Wiley-VCH,
©2003.
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| Series: | Methods and principles in medicinal chemistry ;
v. 18. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
| Summary: | The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so- |
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| Physical Description: | 1 online resource (xxiv, 579 pages) : illustrations |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 3527601473 9783527601479 3527605150 9783527605156 |