http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
"Protein homeostasis is a complex network of components and processes that maintain stability of proteins in cells. Drug discovery and development efforts have focused on developing small molecule agents that bind the target protein with the greatest affinity and most precise selectivity. Impacting protein stability, cellular localization, abundance, interactions and other aspects of protein homeostasis are emerging at the forefront of translational chemical biology and medicinal chemistry efforts"--
Front Matter -- Protein Folding and Quality Control in Drug Discovery. Epichaperomes as a Gateway to Understanding, Diagnosing, and Treating Disease Through Rebalancing Protein-Protein Interaction Networks / Chander S Digwal, Sahil Sharma, Anand R Santhaseela, Stephen D Ginsberg, Gabriela Chiosis -- Stability of Steroid Hormone Receptors / Zachary J Gale-Day, Jason E Gestwicki -- Pharmacological Chaperones / Suli-Anne Laurin, Sajjad Ahrari, Michel Bouvier -- Protein Degradation and Clearance as Drug Targeting Opportunities. Exploiting the Proteasome for Disease Treatment / Gwen R Buel, Xiuxiu Lu, Kylie J Walters -- Targeting the Ubiquitination Cascade for Drug Discovery / Qi Liu, Gabriel LaPlante, Wei Zhang -- Understanding, Targeting, and Hijacking Autophagy / Hongguang Xia, Xiaoyan Xu, Mengxin Zhou, Manke Zhang, Lingzhi Ye -- Deubiquitinating Enzymes / Xiaoxi Liu, Laura Doherty, Alejandra Felix, Sara Buhrlage -- Redirecting Protein Degradation Processes for Drug Development. History of IMiDs and Protein Degradation as a Pharmacological Modality / Junichi Yamamoto, Tomoko Asatsuma-Okumura, Takumi Ito, Yuki Yamaguchi, Hiroshi Handa -- PROTAC Degraders / Alessio Ciulli, Oliver Hsia -- Biochemical Principles of Targeted Protein Degradation / Roman V Agafonov, Richard W Deibler, William A Elam, Joe S Patel, Stewart L Fisher -- Pharmacology of PROTAC Degrader Molecules / Andy Pike, Sofia Guzzetti, Pablo M Gutierrez, James S Scott -- Emerging Technologies and Future Opportunities. Proximity-Inducing Bifunctional Molecules Beyond PROTACs / Sophia Lai, Ashley E Modell, Amit Choudhary -- Strategies for Tag-Based Protein Control / Behnam Nabet, Nathanael S Gray, Fleur M Ferguson -- Targeted Protein Degradation in Antiviral Drug Discovery / Mélissanne Wispelaere, Priscilla L Yang -- Beyond Inhibition / Milka Kostic, Lyn H Jones -- Index.
edited by Milka Kostic and Lyn H. Jones.
Includes bibliographical references and index.