rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Protein homeostasis in drug discovery
    sub title: a chemical biology perspective
  name:
    name part: Kostic, Milka
    role:
      role term: editor.
  name:
    name part: Jones, Lyn H.
    role:
      role term: editor.
  type of resource: text
  origin info:
    place:
      place term: nju
    date issued: 2023
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  abstract: "Protein homeostasis is a complex network of components and processes that maintain stability of proteins in cells. Drug discovery and development efforts have focused on developing small molecule agents that bind the target protein with the greatest affinity and most precise selectivity. Impacting protein stability, cellular localization, abundance, interactions and other aspects of protein homeostasis are emerging at the forefront of translational chemical biology and medicinal chemistry efforts"--
  table of contents: Front Matter -- Protein Folding and Quality Control in Drug Discovery. Epichaperomes as a Gateway to Understanding, Diagnosing, and Treating Disease Through Rebalancing Protein-Protein Interaction Networks / Chander S Digwal, Sahil Sharma, Anand R Santhaseela, Stephen D Ginsberg, Gabriela Chiosis -- Stability of Steroid Hormone Receptors / Zachary J Gale-Day, Jason E Gestwicki -- Pharmacological Chaperones / Suli-Anne Laurin, Sajjad Ahrari, Michel Bouvier -- Protein Degradation and Clearance as Drug Targeting Opportunities. Exploiting the Proteasome for Disease Treatment / Gwen R Buel, Xiuxiu Lu, Kylie J Walters -- Targeting the Ubiquitination Cascade for Drug Discovery / Qi Liu, Gabriel LaPlante, Wei Zhang -- Understanding, Targeting, and Hijacking Autophagy / Hongguang Xia, Xiaoyan Xu, Mengxin Zhou, Manke Zhang, Lingzhi Ye -- Deubiquitinating Enzymes / Xiaoxi Liu, Laura Doherty, Alejandra Felix, Sara Buhrlage -- Redirecting Protein Degradation Processes for Drug Development. History of IMiDs and Protein Degradation as a Pharmacological Modality / Junichi Yamamoto, Tomoko Asatsuma-Okumura, Takumi Ito, Yuki Yamaguchi, Hiroshi Handa -- PROTAC Degraders / Alessio Ciulli, Oliver Hsia -- Biochemical Principles of Targeted Protein Degradation / Roman V Agafonov, Richard W Deibler, William A Elam, Joe S Patel, Stewart L Fisher -- Pharmacology of PROTAC Degrader Molecules / Andy Pike, Sofia Guzzetti, Pablo M Gutierrez, James S Scott -- Emerging Technologies and Future Opportunities. Proximity-Inducing Bifunctional Molecules Beyond PROTACs / Sophia Lai, Ashley E Modell, Amit Choudhary -- Strategies for Tag-Based Protein Control / Behnam Nabet, Nathanael S Gray, Fleur M Ferguson -- Targeted Protein Degradation in Antiviral Drug Discovery / Mélissanne Wispelaere, Priscilla L Yang -- Beyond Inhibition / Milka Kostic, Lyn H Jones -- Index.
  note: edited by Milka Kostic and Lyn H. Jones.
  note: Includes index.
  note: Includes bibliographical references and index.
  subject:
    topic: Drug development
  subject:
    topic: Homeostasis
  subject:
    topic: Proteins
    topic: Therapeutic use
  subject:
    topic: Proteostasis
  subject:
    topic: Drug Development
  subject:
    topic: Drug Discovery
  classification: RM301.25
  classification: 615.1/9
  classification: QU 460
  related item:
    title info:
      title: Protein homeostasis in drug discovery
    origin info:
      publisher: Hoboken, NJ : Wiley, 2023
    identifier: (DLC) 2022051934
  identifier: 9781119774181
  identifier: 1119774187
  identifier: 9781119774174
  identifier: 1119774179
  identifier: 9781119774129
  identifier: 9781119774198
  identifier: 1119774195
  identifier: 1119774128
  identifier: 2022051935
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: DLC
    record creation date: 221128
    record change date: 20260214233806.3
    record identifier: in00004687440
    language of cataloging:
      language term: eng