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GPCRs as therapeutic targets /

"This two-volume book is organized into 26 chapters and serves as a resource for any scientists investigating GPCRs, be it in academia or industry. The first volume provides in-depth information about the molecular pharmacology of this important target class and presents up-to-date material on...

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Bibliographic Details
Other Authors: Gilchrist, Annette (Editor)
Format: eBook
Language:English
Published: Hoboken, NJ : Wiley, 2023.
Subjects:
Drug delivery systems.
G proteins > Receptors.
Receptors, G-Protein-Coupled.
Drug Delivery Systems.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • An overview of G protein coupled receptors and their signaling partners
  • Recent advances in orphan GPCRs research and therapeutic potential
  • The Evolution of Our Understanding of GPCRs
  • Approaching GPCR dimers and higher order oligomers using biophysical, biochemical and proteomic methods
  • Arrestin and G protein interactions with GPCRs : a structural perspective
  • GPCRs at endosomes : sorting, signaling, and recycling
  • Post-translational Control of GPCR Signaling
  • GPCR Signaling from Intracellular Membranes
  • Ten years of GPCR structures
  • Activation of class B GPCR by peptide ligands : general structural aspects
  • Dynamical basis of GPCR-G-protein coupling selectivity and promiscuity
  • Virtual Screening and Bioactivity Modeling for G Protein-Coupled Receptors
  • Importance of structure and dynamics in the rational drug design of G protein-coupled receptor (GPCR) modulators
  • Signaling, Physiology and Targeting of GPCR-Regulated Phospholipase C Enzymes
  • G Protein-coupled Receptors in Metabolic Disease
  • Endothelin Receptors in cerebrovascular diseases
  • The calcium-sensing receptor (CaSR) in disease
  • G protein-coupled receptors and their mutations in cancer : a focus on adenosine receptors
  • Dopamine Receptors: Neurotherapeutic Targets for Substance Use Disorders
  • PTHR1 in bone
  • Activators of G-protein Signaling in the normal and diseased kidney
  • Screening and characterization of GPCR-ligand interactions with mass spectrometry-based technologies
  • Bioluminescence resonance energy transfer (BRET) technologies to study GPCRs
  • The Application of 19F NMR to Studies of Protein Function and Drug Screening
  • Chapter X : Optical Approaches for Dissecting GPCR Signaling
  • GPCR Signaling in Nanodomains : Lessons from Single-Molecule Microscopy.