Physiologically based pharmacokinetic (PBPK) modeling and simulations : principles, methods, and applications in the pharmaceutical industry /
"Physiologically based pharmacokinetic modeling (PBPK) is an emerging field with increasing importance in drug discovery and development. It has become a common tool for most pharmaceutical scientists. This is the only book of its kind to serve the rapidly growing PBPK user community, developin...
| Main Author: | |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
Hoboken, NJ :
John Wiley & Sons, Inc.,
2022.
|
| Edition: | Second edition. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Quantitative Systems Pharmacology (QSP) Models or Quantitative Systems Toxicology and Safety (QSTS) 114 3.4.4 PBPK Models to Evaluate Drug-Drug Interactions 115 3.4.5 DDI Risk Assessment with PBPK vs Static Models 118 Keywords 123 References 125 4 PHYSIOLOGICAL MODEL FOR ABSORPTION 129 4.1 Introduction 130 4.2 Drug Absorption and Gut Bioavailability 130 4.2.1 Solubility and Dissolution Rate 130 4.2.2 Permeability: Transcellular, Paracellular, and Carrier-Mediated Pathways 136 4.2.3 Barriers to Membrane Transport - Luminal Degradation,