rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Targeted biomarker quantitation by LC-MS
  title info:
    title: Targeted biomarker quantitation by liquid chromatography-mass spectrometry
  name:
    name part: Weng, Naidong
    role:
      role term: editor.
  name:
    name part: Jian, Wenying
    role:
      role term: editor.
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: nju
    date issued: 2017
    edition: First edition.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  table of contents: Title Page ; Copyright Page; Contents; List of Contributors; Preface; Abbreviations; Part 1 Overview; Chapter 1 Overview of Targeted Quantitation of Biomarkers and Its Applications; 1.1 Introduction; 1.2 Biomarker Definition; 1.3 Current Challenges of a Biomarker; 1.4 Biomarker Validation Process; 1.5 Current Regulatory Requirement for Target Biomarker Quantitation; 1.6 Challenges of Biomarker Quantitation; 1.7 Current Technologies for Biomarker Quantitation; 1.7.1 LC-MS; 1.7.2 GC-MS; 1.7.3 Ligand-Binding Assay ; 1.7.4 Flow Cytometry; 1.7.5 Quantitative PCR (qPCR).
  table of contents: 1.8 Current Biomarker Quantitation Applications; 1.8.1 Protein Biomarkers; 1.8.2 Peptide Biomarkers; 1.8.3 RNA Biomarkers; 1.8.4 Nucleotide Biomarkers; 1.8.5 Small Molecule Biomarkers; 1.9 Conclusion and Future Perspective; References; Chapter 2 Translational Application of Biomarkers; 2.1 Introduction; 2.2 Translational Medicine; 2.3 Biomarkers; 2.4 Biomarker Categories; 2.5 Neurobiological Disorders; 2.6 Cardiovascular Disorders; 2.7 Chronic Obstructive Pulmonary Disease; 2.8 Oncology; 2.9 Biomarker Measurements and Regulatory Considerations; 2.10 Conclusions; Acknowledgment; References.
  table of contents: Chapter 3 Current Regulatory Guidance Pertaining Biomarker Assay Establishment and Industrial Practice of Fit-for-Purpose and Tiered Approach; 3.1 Introduction; 3.2 Current Regulatory Guidance and Interpretation; 3.3 Current Industrial Discussion and Recommendations; 3.4 Considerations for Assay Validation and Sample Analysis; 3.4.1 Sensitivity; 3.4.2 Specificity and Selectivity; 3.4.3 Matrix Effects and Sample Variables; 3.4.3.1 Authentic Analyte/Authentic Matrix Approach; 3.4.3.2 Surrogate Analyte/Authentic Matrix Approach; 3.4.3.3 Authentic Analyte/Surrogate Matrix Approach.
  table of contents: 4.2.1 Importance of Separation; 4.2.2 Basic Principle of LC; 4.2.3 Major Modes of LC Used for Targeted Biomarker Quantitation; 4.2.4 Modern LC Technologies; 4.2.4.1 HPLC and UHPLC; 4.2.4.2 Miniaturized Column LC; 4.2.4.3 2D-LC ; 4.3 Mass Spectrometry; 4.3.1 Major Types of MS Used for Targeted Biomarker Quantitation; 4.3.2 Ionization Techniques; 4.3.3 Ion Mobility; 4.3.4 Fragmentation Mode; 4.3.5 Emerging MS Techniques; 4.3.5.1 MS Imaging; 4.3.5.2 Other Surface Analysis MS Techniques; 4.4 Summary and Future Perspectives; References.
  note: edited by Dr. Naidong Weng and Dr. Wenying Jian, Janssen Research & Development, LLC.
  note: Includes bibliographical references and index.
  subject:
    topic: Liquid chromatography
  subject:
    topic: Mass spectrometry
  subject:
    topic: Biochemical markers
  subject:
    topic: Chromatography, Liquid
    topic: methods
  subject:
    topic: Chromatography, Liquid
  subject:
    topic: Mass Spectrometry
  subject:
    topic: Biomarkers
  classification: QD79.C454 T37 2017
  classification: 572/.36
  related item:
    title info:
      title: Wiley series on pharmaceutical science and biotechnology. Practices, applications, and methods ; 2954
  related item:
    title info:
      title: Target biomarker quantitation by LC-MS
    origin info:
      publisher: Hoboken, NJ : Wiley, 2017
      edition: First edition.
    identifier: (DLC) 2017013161
  identifier: 9781119413066
  identifier: 1119413060
  identifier: 9781119413059
  identifier: 1119413052
  identifier: 9781119413073
  identifier: 1119413079
  identifier: 9781119103066
  identifier: 2017016881
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: DLC
    record creation date: 170406
    record change date: 20260214205942.8
    record identifier: in00004685857
    language of cataloging:
      language term: eng