rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Translational ADMET for drug therapy
    sub title: principles, methods, and pharmaceutical applications
  name:
    name part: Yanni, Souzan
    role:
      role term: creator
    role:
      role term: author.
  type of resource: text
  genre: bibliography
  genre: Electronic book.
  genre: Electronic books.
  origin info:
    place:
      place term: nju
    date issued: 2015
    copyright date: 2015
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  abstract: Serving as a practical handbook about ADMET for drug therapy, this book presents effective technologies, methods, applications, data interpretation, and decision-making tactics for pharmaceutical and preclinical scientists. Chapters cover case studies and in vivo, in vitro, and computational tools for drug discovery and development, with new translational approaches to clinical drug investigations in various human populations.-Illustrates ADME properties, from bedside to bench and bench to bedside, for the design of safe and effective medicine in human populations -Provides examples that demonstrate the integration of in vitro, in vivo, and in silico data to address human PKPD and TKTD and help determine the proper therapeutic dosage -Presents successful tools for evaluating drugs and covers current translational ADMET with regulatory guidelines -Offers a hands-on manual for researchers and scientists to design and execute in vitro, in silico, preclinical, and clinical studies -Includes discussion of IND / NDA filing and drug labeling to support drug registration and approval.
  table of contents: Translational Concept and Determination of Drug Absorption -- Distribution: Principle, Methods, and Applications -- Metabolism: Principle, Methods, and Applications -- Excretion: Principle, Methods, and Applications for Better Therapy -- Drug-Drug Interaction: From Bench to Drug Label -- General Toxicology: Principle, Methods, and Applications -- Toxicokinetics and Toxicity Testing in Drug Development -- PBPK Modeling and In Silico Prediction for ADME and Drug-Drug Interaction -- Translational Tools toward Better Drug Therapy in Human Populations -- Phase 1-Phase 3 Clinical Studies, Procedures, Responsibilities, and Documentation -- Regulatory Submission: MIST and Drug Safety Assessment.
  note: Souzan B. Yanni.
  note: Includes bibliographical references and index.
  subject:
    topic: Pharmacokinetics
  subject:
    topic: Drugs
    topic: Metabolism
    topic: Pharmacokinetics
  subject:
    topic: Drugs
    topic: Testing
  subject:
    topic: Drug development
  subject:
    topic: Chemotherapy
  subject:
    topic: Drug Evaluation, Preclinical
  subject:
    topic: Pharmacokinetics
  subject:
    topic: Drug-Related Side Effects and Adverse Reactions
  subject:
    topic: Pharmaceutical Preparations
    topic: metabolism
  classification: RM301.5 .Y35 2015
  classification: 615.7
  classification: QV 771
  related item:
    title info:
      title: Translational ADMET for drug therapy
    name:
      name part: Yanni, Souzan.
    origin info:
      publisher: Hoboken, New Jersey : John Wiley & Sons, Inc., [2015]
    identifier: (DLC) 2015010195
  identifier: 9781118838419
  identifier: 1118838416
  identifier: 9781118838327
  identifier: 1118838327
  identifier: 9781118838440
  identifier: 1118838440
  identifier: 9781118838273
  identifier: 2015011278
  identifier: EB00665390 Recorded Books
  identifier: 9781118838327 Wiley
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: DLC
    record creation date: 150320
    record change date: 20260214213954.2
    record identifier: in00004682312
    language of cataloging:
      language term: eng