rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: A
    title: handbook for DNA-encoded chemistry
    sub title: theory and applications for exploring chemical space and drug discovery
  name:
    name part: Goodnow, Robert A.
    name part: Jr
    role:
      role term: editor.
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: nju
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  abstract: This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combi.
  table of contents: Just enough knowledge? -- A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry -- A history of DNA-encoding -- DNA-compatible chemistry -- Foundations of a DNA-encoded library (DEL) -- Practices for synthesizing DNA-encoded libraries -- Chemical gene design for DNA-encoded libraries -- Analytical challenges for DNA-encoded library systems -- Information technology: functionality and architectures for DNA-encoding -- Theoretical considerations of the application of DNA-encoded libraries to drug discovery -- Begin with the end in mind : the hit-to-lead process -- Enumeration and visualization of large combinatorial chemical libraries -- Screening large compound collections -- Reported applications of DNA-encoded library chemistry -- Dual-pharmacophore DNA-encoded chemical libraries -- Hit identification and hit follow-up -- Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding -- An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches -- Keeping the promise? an outlook on dna chemical library technology.
  note: edited by Robert A. Goodnow, Jr.
  note: Includes bibliographical references and index.
  subject:
    topic: Combinatorial chemistry
    topic: Technique
  subject:
    topic: DNA
    topic: Synthesis
  subject:
    topic: Combinatorial Chemistry Techniques
    topic: methods
  subject:
    topic: DNA
    topic: chemical synthesis
  subject:
    topic: Drug Discovery
    topic: methods
  subject:
    topic: Gene Library
  subject:
    topic: Small Molecule Libraries
    topic: chemical synthesis
  classification: RS420 .H35 2014
  classification: 615.1/9
  classification: QV 744
  related item:
    title info:
      title: Handbook for DNA-encoded chemistry
    origin info:
      publisher: Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]
    identifier: (DLC) 2013042727
  identifier: 9781118832691
  identifier: 1118832698
  identifier: 9781118832677
  identifier: 1118832671
  identifier: 9781306642514
  identifier: 1306642515
  identifier: 9781118832639
  identifier: 1118832639
  identifier: 9781118487686
  identifier: 9781118832738
  identifier: 1118832736
  identifier: 1118487680
  identifier: 2013046115
  identifier: ECBAC530-4A08-4EBD-A06F-B8AF5C902C02 OverDrive, Inc.
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: DLC
    record creation date: 131115
    record change date: 20260214212359.4
    record identifier: in00004682284
    language of cataloging:
      language term: eng