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Engineering polymer systems for improved drug delivery
Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-
Cover; Title Page; Copyright; CONTENTS; FOREWORD; PREFACE; CONTRIBUTORS; PART I INTRODUCTION; 1 FUNDAMENTALS OF DRUG DELIVERY; 1.1 Introduction: History and Future of Drug Delivery; 1.2 Terminology; 1.3 Basic Pharmacokinetics; 1.4 Basic Pharmacodynamics; 1.5 Mass Transfer; 1.6 Key Points; 1.7 Homework Problems; 2 CHALLENGES OF DRUG DELIVERY; 2.1 Introduction; 2.2 History and Challenges of Drug Delivery; 2.3 Physical Barriers; 2.4 Metabolic and Chemical Concerns; 2.5 Physical Properties of Therapeutics; 2.6 Polymer Carriers as a Solution to Challenges; 2.7 Key Points; 2.8 Homework Problems.
PART II INJECTABLE POLYMERIC DRUG DELIVERY SYSTEMS3 POLYMER-DRUG CONJUGATES; 3.1 Introduction; 3.2 Historical Perspective; 3.3 Polymer-Drug Conjugates: Biological Rationale; 3.4 Structural Features of Polymer-Drug Conjugates; 3.5 Making a Polymer-Drug Conjugate; 3.6 Current Challenges and Future Perspectives; 3.7 Key Points; 3.8 Worked Example; 3.9 Homework Problems; 4 POLYMERIC MICROPARTICLES; 4.1 Introduction; 4.2 The Rationale for Microparticles; 4.3 Defining the Design Criteria; 4.4 Polymer Selection; 4.5 Microparticle Synthesis; 4.6 Microparticle Characterization Methods.
4.7 Drug Release from Microparticles4.8 Microparticle Design Examples; 4.9 Key Points; 4.10 Worked Example; 4.11 Homework Problems; 5 POLYMERIC NANOPARTICLES; 5.1 Introduction; 5.2 PNP Design; 5.3 PNP Formulation Methods and Targeting; 5.4 Nanoparticle Targeting Overview; 5.5 PNP Characterization; 5.6 Major Clinical Achievements; 5.7 Key Points; 5.8 Worked Example; 5.9 Homework Problems; 6 BLOCK COPOLYMER MICELLES AND VESICLES FOR DRUG DELIVERY; 6.1 Introduction; 6.2 Drug Encapsulation and Release; 6.3 Bioavailability and Biodistribution; 6.4 Stimuli Responsiveness; 6.5 The Immune System.
6.6 Gene Therapy6.7 Cancer Therapy; 6.8 Conclusions; 6.9 Key Points; 6.10 Homework Problems; PART III IMPLANTABLE POLYMERIC DRUG DELIVERY SYSTEMS; 7 IMPLANTABLE DRUG DELIVERY SYSTEMS; 7.1 Introduction; 7.2 Nondegradable Polymeric Implants; 7.3 Biodegradable Polymeric Implants; 7.4 Conclusions and Future Perspectives; 7.5 Key Points; 7.6 Homework Problems; 8 POLYMERIC DRUG DELIVERY SYSTEMS IN TISSUE ENGINEERING; 8.1 Introduction; 8.2 Wound Healing as a Prototype for Adult Tissue Generation; 8.3 Bioactive Factors in Tissue Engineering and Regenerative Medicine.
8.4 Delivery of Growth Factors in Tissue Engineering and Regenerative Medicine8.5 Key Points; 8.6 Worked Example; 8.7 Homework Problems; PART IV ORAL POLYMERIC DRUG DELIVERY SYSTEMS; 9 ORAL CONTROLLED-RELEASE POLYMERIC DRUG DELIVERY SYSTEMS; 9.1 Introduction; 9.2 Release Mechanisms of Oral Polymeric Dosage Forms; 9.3 Oral Polymeric Release Modifiers; 9.4 Manufacturing Technologies and Industrial Applications of Controlled Release; 9.5 Worked Example; 9.6 Key Points; 9.7 Homework Problems; 10 MUCOADHESIVE DRUG DELIVERY SYSTEMS; 10.1 Introduction; 10.2 Factors Affecting Mucoadhesion.
edited by Rebecca A. Bader, David A. Putnam.
Includes bibliographical references and index.
Hoboken, New Jersey : John Wiley & Sons, Inc., [2013]