Signaling pathways in liver diseases /
Signalling Pathways in Liver Diseases 3E again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signalling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in...
| Other Authors: | , |
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| Format: | eBook |
| Language: | English |
| Published: |
Chichester, West Sussex, UK ; Hoboken, NJ, USA :
John Wiley & Sons, Ltd,
2016.
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| Edition: | Third edition. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Title Page; Copyright Page; Contents; List of Contributors; Chapter 1 Hepatocytes; Introduction; Liver and hepatocyte development; Phenotype and regeneration of the mature hepatocyte; Metabolic functions of the liver; Resorption, storage, and synthesis; Detoxification and excretion; Detoxification of specific substances; Excretion; Multiple choice questions; References; Chapter 2 Signaling pathways in biliary epithelial cells; Introduction; Membrane receptors; Cyclic adenosine 3', 5'-monophosphate (cAMP); Cytosolic Ca2+; Protein kinase C; Mitogen-activated protein kinase signaling.
- Hedgehog pathway Wnt pathway; Autophagy; Senescence of activated stellate cells; miRNAs and hepatic stellate cells; Conclusion; Multiple choice questions; References; Chapter 4 Kupffer cells; Introduction; Markers, origin, and heterogeneity of Kupffer cells; M1 versus M2 polarization in Kupffer cells; Lipopolysaccharide signaling and endotoxin tolerance; Experimental approaches to deplete Kupffer cells in vivo; Role of Kupffer cells in liver disease; Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis; Alcoholic liver disease; Liver regeneration; Liver fibrosis and cirrhosis.
- Ischemia-reperfusion liver injury Primary and metastatic liver tumors; Infectious diseases; Clinical applications and future perspectives; Acknowledgment; Multiple choice questions; References; Chapter 5 Hepatic sinusoidal endothelial cells; Development and structure; Cellular functions; Filtration via fenestrae; Diapedesis; Nitric oxide signaling; Endocytosis; Bacterial processing; Liver regeneration; Pathobiology; Fibrosis and cirrhosis; Alcoholic liver disease; Nonalcoholic fatty liver disease; Hepatic malignancies; Drug toxicity; Ischemia-reperfusion injury; Aging process; Conclusion.
- Multiple choice questions References; Chapter 6 Extracellular matrix; Introduction; Components of the extracellular matrix in liver (Figure 6.1); The collagen scaffold; Proteoglycans; Laminin; Fibronectin; Matricellular proteins; Changes in the extracellular matrix from normal to fibrotic liver; Pathways of cell-matrix interaction; Integrin family; ADAM molecules; Discoidin domain receptors; Growth factors in ECM (Figure 6.4); The extracellular matrix and the stem cell niche; Metalloproteinases and their inhibitors; Conclusion; Multiple choice questions; References.