http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
application to drug discovery and challenges to pharmaceutical development
1 online resource (xiv, 310 pages : : illustrations.)
"RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects"--Provided by publisher.
1. RNA Interference: What is It? / James A. Birchler -- 2. Nucleic Acids as Regulatory Molecules / Yanlin Guo -- 3. Use of siRNA Oligonucleotides to Study Gene Function / Adam N. Harris -- 4. Genome Scanning by RNA Interference / Oliver C. Steinbach -- 5. Discovery of New siRNA Delivery Agents / Steven C. Quay -- 6. siRNA Delivery Vehicles / Mark A. Behlke -- 7. Interferon, Cytokine Induction, and Other Potential in vivo Toxicities / Ian Maclachlan -- 8. Application of RNA Interference to Viral Diseases / Stephen Mark Tompkins.
Includes bibliographical references and index.