http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (x, 319 pages) : illustrations (some color)
Fatty liver disease, especially non-alcoholic steatohepatitis (NASH), is emerging as the most common form of liver disease - affecting at least 5% of the population of western countries with increasing incidence in developing economies in other continents (particularly Asia, Australia, South America and South Africa). NASH is the form of fatty liver disorder which can result in cirrhosis, particularly in those with diabetes or who are overweight, yet it is still not widely recognised as the most common form of liver disease. This book explains what NASH is, why it happens, who gets it, how it can result in cirrhosis, when to think about it, how to select practical management between those with a minor abnormality from those who may have cirrhosis, and how to prevent and treat this ubiquitous condition. Fatty Liver Diseases: NASH and Related Disorders is an unusual book: it combines a practical approach for students and physicians concerned with the problem with a clear overview on the causative mechanisms.; It should appeal to doctors and other health care workers who encounter this problem, as well as to pathologists and investigators interested in the field of liver disease. There is a dearth of assembled information about NASH: such information is sought by physicians of various backgrounds, and detailed information is required by gastroenterologist, hepatologists, general physicians, diabetologists, nutritionalists and pathologists. Information on the diagnosis, management and understanding of this disease is only available in recent reviews - it is not covered in standard texts and there is no specific book available on the subject so far. The reader will benefit from the book by improving their diagnostic acumen for people with abnormal liver tests, improving knowledge about an important subject that will assist them in specialist or undergraduate exams, and will improve management of a common disorder.
Overview: an introduction to NASH and related fatty liver disorders / Geoffrey C. Farrell [and others] -- Pathology of hepatic steatosis, non-alcoholic steatohepatitis (NASH) and related conditions / Pauline de la M. Hall & Richard Kirsch -- The epidemiology and risk factors of NASH / Arthur J. Mccullough -- Insulin resistance in non-alcoholic fatty liver disease: potential mechanisms and therapies / Varman T. Samuel & Gerald I. Shulman -- NASH as part of the metabolic (insulin resistance) syndrome / Giulio Marchesini & Elisabetta Bugianesi -- NASH is a genetically determined disease / C.P. Day & A.K. Daly -- The pathogenesis of non-alcoholic steatohepatitis: human studies / Arun J. Sanyal -- Animal models of steatohepatitis / Geoffrey C. Farrell -- Fatty acid metabolism and lipotoxicity in the pathogenesis of NASH/NAFLD / Nathan M. Bass & Raphael B. Merriman -- Cytokines and inflammatory recruitment in NASH: experimental and human studies / Z. Li & A.M. Diehl -- Mitochondrial injury and NASH / Bernard Fromenty & Dominique Pessayre -- Cell biology of NASH: fibrosis and cell proliferation / Isabelle A. Leclercq & Yves Horsmans -- Clinical manifestations and diagnosis of NAFLD / Stephen A. Harrison & Brent Neuschwander-Tetri.
The clinical outcome of NAFLD including cryptogenic cirrhosis / Stephen H. Caldwell & Anita Impagliazzo Hylton -- Practical approach to the diagnosis and management of people with fatty liver diseases / Jacob George & Geoffrey C. Farrell -- Management of NASH: current and future perspectives on treatment / Paul Angulo & Keith D. Lindor -- Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and orthotopic liver transplantation / Anne Burke & Michael R. Lucey -- Non-alcoholic steatohepatitis (NASH)/non-alcoholic fatty liver disease (NAFLD) is not just a 'Western' problem: some perspectives on NASH/NAFLD from the East / Shivakumar Chitturi & Jacob George -- Paediatric NASH / J. Lavine and J.B. Schwimmer -- Steatohepatitis due to intestinal bypass / Christiane Bode & J. Christian Bode -- Specific disorders associated with non-alcoholic fatty liver disease (NAFLD) / Geraldine M. Grant, Vikas Chandhoke & Zobair M. Younossi -- Hepatocellular carcinoma in non-alcoholic fatty liver disease / Vlad Ratziu & Thierry Poynard -- Does NASH or NAFLD contribute to co-morbidity of other liver diseases? / Andrew D. Clouston & Elizabeth E. Powell.
edited by Geoffrey C. Farrell [and others].
Includes bibliographical references and index.