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Evaluation of drug candidates for preclinical development : pharmacokinetics, metabolism, pharmaceutics, and toxicology /

Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, dr...

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Bibliographic Details
Other Authors: Han, Chao, Davis, Charles B. (Charles Baldwin), Wang, Binghe, 1962-
Format: eBook
Language:English
Published: Hoboken, N.J. : John Wiley & Sons, ©2010.
Subjects:
Drug development.
Pharmacokinetics.
Drugs > Metabolism.
Drug Evaluation, Preclinical.
Drug Discovery.
Drug Industry > standards.
Pharmaceutical Preparations > metabolism.
Pharmacology > methods.
Electronic book.
Electronic books.
Online Access:Connect to the full text of this electronic book
Description
Summary:Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, assessing stability, ways to optimize drug formulation, toxicology and toxicokinetics, and more. Readers will understand why absorption-distribution-metabolism-excretion-toxicology (ADMET) is key in drug developmen.
Item Description:Includes index.
Physical Description:1 online resource
Bibliography:Includes bibliographical references and index.
ISBN:9780470574898
0470574895
9780470574881
0470574887
1282684906
9781282684904
0470044918
9780470044919